Discovery of 4-alkoxy-6-methylpicolinamide negative allosteric modulators of metabotropic glutamate receptor subtype 5.
CNS
Metabotropic glutamate receptor
Negative allosteric modulator (NAM)
Structure-Activity Relationship (SAR)
mGlu(5)
Journal
Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377
Informations de publication
Date de publication:
01 01 2019
01 01 2019
Historique:
received:
25
09
2018
revised:
06
11
2018
accepted:
08
11
2018
pubmed:
18
11
2018
medline:
5
11
2019
entrez:
18
11
2018
Statut:
ppublish
Résumé
This letter describes the further chemical optimization of VU0424238 (auglurant), an mGlu
Identifiants
pubmed: 30446311
pii: S0960-894X(18)30882-5
doi: 10.1016/j.bmcl.2018.11.017
pmc: PMC6295259
mid: NIHMS1512645
pii:
doi:
Substances chimiques
Ligands
0
Picolinic Acids
0
Receptor, Metabotropic Glutamate 5
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
47-50Subventions
Organisme : NIMH NIH HHS
ID : R01 MH062646
Pays : United States
Organisme : NINDS NIH HHS
ID : R37 NS031373
Pays : United States
Organisme : NIMH NIH HHS
ID : U19 MH097056
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD083211
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
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