Chemogenetic Manipulations of Ventral Tegmental Area Dopamine Neurons Reveal Multifaceted Roles in Cocaine Abuse.

Animals Behavior, Animal Cocaine-Related Disorders / genetics Dopaminergic Neurons / drug effects Drug-Seeking Behavior GTP-Binding Proteins / physiology Limbic System / drug effects Male Motor Activity / drug effects Prosencephalon / drug effects Rats Rats, Transgenic Recurrence Reward Self Administration Signal Transduction / drug effects Stress, Psychological / psychology Ventral Tegmental Area / drug effects
DREADDs addiction conditioned cues motivation neural circuits reinstatement

Journal

The Journal of neuroscience : the official journal of the Society for Neuroscience
ISSN: 1529-2401
Titre abrégé: J Neurosci
Pays: United States
ID NLM: 8102140

Informations de publication

Date de publication:
16 01 2019
Historique:
received: 04 02 2018
revised: 04 10 2018
accepted: 19 10 2018
pubmed: 18 11 2018
medline: 17 10 2019
entrez: 18 11 2018
Statut: ppublish

Résumé

Ventral tegmental area (VTA) dopamine (DA) neurons perform diverse functions in motivation and cognition, but their precise roles in addiction-related behaviors are still debated. Here, we targeted VTA DA neurons for bidirectional chemogenetic modulation during specific tests of cocaine reinforcement, demand, and relapse-related behaviors in male rats, querying the roles of DA neuron inhibitory and excitatory G-protein signaling in these processes. Designer receptor stimulation of G

Identifiants

DOI: 10.1523/JNEUROSCI.0537-18.2018 PMID: 30446532 PMC: PMC6335749
pubmed: 30446532
pii: JNEUROSCI.0537-18.2018
doi: 10.1523/JNEUROSCI.0537-18.2018
pmc: PMC6335749
doi:

Substances chimiques

GTP-Binding Proteins EC 3.6.1.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

503-518

Subventions

Organisme : NIDA NIH HHS
ID : F31 DA036989
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA031900
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA033342
Pays : United States
Organisme : NIDA NIH HHS
ID : P50 DA015369
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA046476
Pays : United States
Organisme : NIDA NIH HHS
ID : F31 DA042505
Pays : United States
Organisme : NIDA NIH HHS
ID : R00 DA035251
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA007288
Pays : United States
Organisme : NIDA NIH HHS
ID : P50 DA044118
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR001415
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA006214
Pays : United States
Organisme : NIDA NIH HHS
ID : R00 DA040004
Pays : United States
Organisme : NIDA NIH HHS
ID : K99 DA035251
Pays : United States

Informations de copyright

Copyright © 2019 the authors 0270-6474/19/390503-16$15.00/0.

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Auteurs

Stephen V Mahler (SV)

Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697, mahlers@uci.edu.
Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425-8610.
ORCID: 0000-0002-8698-0905

Zachary D Brodnik (ZD)

Department of Neurobiology and Anatomy, Drexel University, Philadelphia, Pennsylvania 19129, and.
ORCID: 0000-0002-2847-2849

Brittney M Cox (BM)

Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697.
Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425-8610.
ORCID: 0000-0002-7118-5300

William C Buchta (WC)

Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425-8610.

Brandon S Bentzley (BS)

Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425-8610.
ORCID: 0000-0001-6014-4514

Julian Quintanilla (J)

Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697.

Zackary A Cope (ZA)

Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425-8610.

Edwin C Lin (EC)

Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425-8610.

Matthew D Riedy (MD)

Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425-8610.

Michael D Scofield (MD)

Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425-8610.

Justin Messinger (J)

Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425-8610.

Christina M Ruiz (CM)

Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697.

Arthur C Riegel (AC)

Department of Neuroscience, Medical University of South Carolina, Charleston, South Carolina 29425-8610.
ORCID: 0000-0001-7758-4436

Rodrigo A España (RA)

Department of Neurobiology and Anatomy, Drexel University, Philadelphia, Pennsylvania 19129, and.

Gary Aston-Jones (G)

Brain Health Institute, Rutgers University, Piscataway, New Jersey 08854.
ORCID: 0000-0002-5034-3816

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chemogenetic Manipulations of Ventral...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement animal › Chemogenetic Manipulations of Ventral...
questionsmedicales.fr › Troubles mentaux › Troubles liés à une substance › Troubles liés à la cocaïne › Chemogenetic Manipulations of Ventral...
questionsmedicales.fr › Cellules › Neurones › Neurones dopaminergiques › Chemogenetic Manipulations of Ventral...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement de recherche de substances › Chemogenetic Manipulations of Ventral...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Chemogenetic Manipulations of Ventral...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Système limbique › Chemogenetic Manipulations of Ventral...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Activité motrice › Chemogenetic Manipulations of Ventral...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Chemogenetic Manipulations of Ventral...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Chemogenetic Manipulations of Ventral...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rats transgéniques › Chemogenetic Manipulations of Ventral...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Récidive › Chemogenetic Manipulations of Ventral...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Renforcement (psychologie) › Récompense › Chemogenetic Manipulations of Ventral...
questionsmedicales.fr › Thérapeutique › Autoadministration › Chemogenetic Manipulations of Ventral...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Chemogenetic Manipulations of Ventral...
questionsmedicales.fr › Phénomènes psychologiques › Stress psychologique › Chemogenetic Manipulations of Ventral...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Tronc cérébral › Mésencéphale › Pédoncule cérébral › Tegmentum du mésencéphale › Aire tegmentale ventrale › Chemogenetic Manipulations of Ventral...