Prostaglandin E
Adult
Anti-Inflammatory Agents, Non-Steroidal
/ administration & dosage
Aspirin
/ administration & dosage
Asthma
/ diagnosis
Asthma, Aspirin-Induced
/ diagnosis
Biomarkers
Dinoprostone
/ metabolism
Disease Susceptibility
Female
Humans
Leukotriene E4
/ urine
Male
Middle Aged
Phenotype
Respiratory Function Tests
Sputum
/ metabolism
eicosanoids
induced sputum
nonsteroidal anti-inflammatory drug-exacerbated respiratory disease
oral aspirin challenge
prostaglandins
Journal
Allergy
ISSN: 1398-9995
Titre abrégé: Allergy
Pays: Denmark
ID NLM: 7804028
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
24
10
2017
revised:
01
11
2018
accepted:
05
11
2018
pubmed:
18
11
2018
medline:
19
5
2020
entrez:
18
11
2018
Statut:
ppublish
Résumé
A special regulatory role for prostaglandin E To investigate the effect of systemic aspirin (acetylsalicylic acid) administration on airway PGE Induced sputum (IS) was collected from patients with NERD (n = 26), ATA-CRSwNP (n = 17), and HC (n = 21) at baseline and after aspirin challenge. Sputum differential cell count and IS supernatant (ISS) levels of prostanoids, PGE NERD subjects had elevated sputum eosinophilic count as compared to ATA-CRSwNP and HC (median NERD 9.1%, ATA-CRSwNP 2.1%, and HC 0.4%; P < 0.01). Baseline ISS levels of PGE Aspirin-precipitated bronchoconstriction is associated with a decrease in airway PGE
Sections du résumé
BACKGROUND
A special regulatory role for prostaglandin E
OBJECTIVE
To investigate the effect of systemic aspirin (acetylsalicylic acid) administration on airway PGE
METHODS
Induced sputum (IS) was collected from patients with NERD (n = 26), ATA-CRSwNP (n = 17), and HC (n = 21) at baseline and after aspirin challenge. Sputum differential cell count and IS supernatant (ISS) levels of prostanoids, PGE
RESULTS
NERD subjects had elevated sputum eosinophilic count as compared to ATA-CRSwNP and HC (median NERD 9.1%, ATA-CRSwNP 2.1%, and HC 0.4%; P < 0.01). Baseline ISS levels of PGE
CONCLUSION
Aspirin-precipitated bronchoconstriction is associated with a decrease in airway PGE
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Biomarkers
0
Leukotriene E4
75715-89-8
Dinoprostone
K7Q1JQR04M
Aspirin
R16CO5Y76E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
922-932Subventions
Organisme : Narodowe Centrum Nauki
ID : UMO-2013/11/B/NZ6/02034
Pays : International
Organisme : Faculty of Applied Mathematics AGH UST Statutory Task
Pays : International
Informations de copyright
© 2018 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.