Prognostic value of serum liver enzymes in oral and oropharynx squamous cell carcinomas.
Adenosine Deaminase
/ blood
Adult
Age Factors
Aged
Aged, 80 and over
Biomarkers, Tumor
/ blood
Carcinoma, Squamous Cell
/ diagnosis
Female
Humans
Lymph Nodes
/ pathology
Lymphatic Metastasis
Male
Middle Aged
Mouth Neoplasms
/ diagnosis
Multivariate Analysis
Oropharyngeal Neoplasms
/ diagnosis
Prognosis
Retrospective Studies
Survival Rate
Young Adult
oral and oropharynx
prognosis
serum adenosine deaminase
squamous cell carcinoma
Journal
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
ISSN: 1600-0714
Titre abrégé: J Oral Pathol Med
Pays: Denmark
ID NLM: 8911934
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
06
08
2018
revised:
13
10
2018
accepted:
09
11
2018
pubmed:
18
11
2018
medline:
18
5
2019
entrez:
18
11
2018
Statut:
ppublish
Résumé
Serum liver enzymes, which catalyze relevant catabolic pathways, have been indicated to be diagnostic and prognostic tools for several malignant tumors. The correlation between serum liver enzymes levels and survival in patients with oral and oropharynx squamous cell carcinomas (OSCC) is still absent. Here, we conducted a study focusing on predictive value of serum liver enzymes in terms of prognosis in the patients. A retrospective study including 134 OSCC patients from years 2009 to 2014 was performed to investigate the association between levels of pre-treatment serum liver enzymes, various clinical parameters and prognostic outcomes, which are overall survival (OS) and disease-free survival (DFS). Log-rank tests with Kaplan-Meier method were used to detect potential prognostic biomarkers. Multivariate analyses by Cox proportional hazards model were used to identify significant predictors of prognosis. Serum adenosine deaminase (ADA) level was associated with patients' OS and DFS by univariate analyses (P = 0.006 and P = 0.024, respectively). Multivariate analyses showed that higher serum ADA (>17.2 U/L) (P = 0.019) as well as positive lymph node status (P = 0.035) independently predicted worse OS of patients with OSCC. In addition, older age (≥60 years) (P = 0.043) and positive lymph node status (P = 0.027) were independently prognostic parameters for poorer DFS. Pre-operative serum ADA levels may serve as a reliable independent prognostic predictor for OS in OSCC patients.
Sections du résumé
BACKGROUND
BACKGROUND
Serum liver enzymes, which catalyze relevant catabolic pathways, have been indicated to be diagnostic and prognostic tools for several malignant tumors. The correlation between serum liver enzymes levels and survival in patients with oral and oropharynx squamous cell carcinomas (OSCC) is still absent. Here, we conducted a study focusing on predictive value of serum liver enzymes in terms of prognosis in the patients.
METHODS
METHODS
A retrospective study including 134 OSCC patients from years 2009 to 2014 was performed to investigate the association between levels of pre-treatment serum liver enzymes, various clinical parameters and prognostic outcomes, which are overall survival (OS) and disease-free survival (DFS). Log-rank tests with Kaplan-Meier method were used to detect potential prognostic biomarkers. Multivariate analyses by Cox proportional hazards model were used to identify significant predictors of prognosis.
RESULTS
RESULTS
Serum adenosine deaminase (ADA) level was associated with patients' OS and DFS by univariate analyses (P = 0.006 and P = 0.024, respectively). Multivariate analyses showed that higher serum ADA (>17.2 U/L) (P = 0.019) as well as positive lymph node status (P = 0.035) independently predicted worse OS of patients with OSCC. In addition, older age (≥60 years) (P = 0.043) and positive lymph node status (P = 0.027) were independently prognostic parameters for poorer DFS.
CONCLUSIONS
CONCLUSIONS
Pre-operative serum ADA levels may serve as a reliable independent prognostic predictor for OS in OSCC patients.
Substances chimiques
Biomarkers, Tumor
0
Adenosine Deaminase
EC 3.5.4.4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
36-42Subventions
Organisme : Priority Academic Program Development of Jiangsu Higher Education Institutions
ID : PAPD, 2014-37
Organisme : Jiangsu Provincial Medical Innovation Team
ID : CXTDA2017036
Organisme : Jiangsu Provincial Medical Youth Talent
ID : QNRC2016854
Organisme : Natural Science Foundation of Jiangsu Province of China
ID : BK20171488
Organisme : National Natural Science Foundation of China
ID : 81402236
Organisme : National Natural Science Foundation of China
ID : 81772887
Informations de copyright
© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.