Retinal microvasculature changes in amyloid-negative subcortical vascular cognitive impairment compared to amyloid-positive Alzheimer's disease.
Aged
Aged, 80 and over
Alzheimer Disease
/ complications
Amyloid beta-Peptides
/ metabolism
Analysis of Variance
Aniline Compounds
/ pharmacokinetics
Dementia, Vascular
/ diagnostic imaging
Female
Humans
Linear Models
Magnetic Resonance Imaging
Male
Microvessels
/ diagnostic imaging
Middle Aged
Neuropsychological Tests
Positron-Emission Tomography
Retina
/ pathology
Risk Factors
Thiazoles
/ pharmacokinetics
White Matter
/ diagnostic imaging
Alzheimer's disease
Amyloid
Cerebral small vessel diseases
Retinal vessels
Vascular dementia
Journal
Journal of the neurological sciences
ISSN: 1878-5883
Titre abrégé: J Neurol Sci
Pays: Netherlands
ID NLM: 0375403
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
25
04
2018
revised:
25
10
2018
accepted:
29
10
2018
pubmed:
18
11
2018
medline:
23
7
2019
entrez:
18
11
2018
Statut:
ppublish
Résumé
To investigate small vessel abnormalities in patients with cognitive impairment, we compared retinal microvascular alterations between patients with cognitive impairment related to Alzheimer's disease (ADCI) and those with subcortical vascular cognitive impairment (SVCI). We prospectively recruited 29 amyloid-positive ADCI patients, 28 amyloid-negative SVCI patients that were confirmed by Compared to NC individuals, the SVCI patients had smaller total and arteriolar fractal dimensions, whereas there was no significant difference of fractal dimension between ADCI and NC. Other retinal variables did not differ among the three groups. A significant correlation existed between fractal dimension and WMH volume. Retinal microvascular alterations, especially retinal fractal dimension, may be useful markers that reflect cerebral microvascular changes in patients with SVCI as opposed to ADCI, who had no definite difference in retinal variables compared to the NC group.
Sections du résumé
BACKGROUND AND PURPOSE
To investigate small vessel abnormalities in patients with cognitive impairment, we compared retinal microvascular alterations between patients with cognitive impairment related to Alzheimer's disease (ADCI) and those with subcortical vascular cognitive impairment (SVCI).
METHODS
We prospectively recruited 29 amyloid-positive ADCI patients, 28 amyloid-negative SVCI patients that were confirmed by
RESULTS
Compared to NC individuals, the SVCI patients had smaller total and arteriolar fractal dimensions, whereas there was no significant difference of fractal dimension between ADCI and NC. Other retinal variables did not differ among the three groups. A significant correlation existed between fractal dimension and WMH volume.
CONCLUSIONS
Retinal microvascular alterations, especially retinal fractal dimension, may be useful markers that reflect cerebral microvascular changes in patients with SVCI as opposed to ADCI, who had no definite difference in retinal variables compared to the NC group.
Identifiants
pubmed: 30447606
pii: S0022-510X(18)30445-3
doi: 10.1016/j.jns.2018.10.025
pii:
doi:
Substances chimiques
2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
0
Amyloid beta-Peptides
0
Aniline Compounds
0
Thiazoles
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
94-101Informations de copyright
Copyright © 2018. Published by Elsevier B.V.