Characterization of 3-dimensional papillary muscle displacement in in vivo ovine models of ischemic/functional mitral regurgitation.

Anatomic Landmarks Animals Disease Models, Animal Fiducial Markers Fluoroscopy Imaging, Three-Dimensional / instrumentation Mitral Valve / diagnostic imaging Mitral Valve Insufficiency / diagnostic imaging Myocardial Infarction / complications Papillary Muscles / diagnostic imaging Predictive Value of Tests Sheep, Domestic
cardiac intervention cardiomyopathy heart failure mitral regurgitation mitral valve mitral valve repair pathophysiology surgery techniques

Journal

The Journal of thoracic and cardiovascular surgery
ISSN: 1097-685X
Titre abrégé: J Thorac Cardiovasc Surg
Pays: United States
ID NLM: 0376343

Informations de publication

Date de publication:
04 2019
Historique:
received: 12 04 2018
revised: 11 09 2018
accepted: 18 09 2018
pubmed: 19 11 2018
medline: 25 2 2020
entrez: 19 11 2018
Statut: ppublish

Résumé

Papillary muscle (PM) displacement contributes to ischemic/functional mitral regurgitation (IMR/FMR). The displaced PMs pull the mitral leaflets into the left ventricle (ie, toward the apex) thus hampering leaflet coaptation. Intuitively apical leaflet tethering results from apical PM displacement. The 3-dimensional directions of PM displacement are, however, incompletely characterized. Data from in vivo ovine models of IMR (6-8 weeks of posterolateral infarction, n = 12) and FMR (9-21 days of rapid left ventricular pacing, n = 11) were analyzed. All sheep had radiopaque markers implanted on the anterior and posterior PM (PPM) tips, around the mitral annulus, and on the left ventricular apex. To explore 3-dimensional PM displacement directions, differences in marker coordinates were calculated at end-systole before and during IMR/FMR using a right-handed coordinate system centered on the mitral annular "saddle horn" with the y-axis passing through the apical marker. No apical PM displacement was observed during either IMR or FMR. The anterior PM displaced laterally during FMR. Posterolateral PPM displacement was observed during IMR and FMR. Experimental in vivo ovine models suggest posterolateral PPM displacement as a predominant pathomechanism leading to apical leaflet tethering during IMR/FMR.

Identifiants

DOI: 10.1016/j.jtcvs.2018.09.069 PMID: 30447965 PMC: PMC6431277
pubmed: 30447965
pii: S0022-5223(18)32577-7
doi: 10.1016/j.jtcvs.2018.09.069
pmc: PMC6431277
mid: NIHMS1512831
pii:
doi:

Types de publication

Journal Article Video-Audio Media

Langues

eng

Sous-ensembles de citation

IM

Pagination

1444-1449

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL029589
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL067025
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2018 The American Association for Thoracic Surgery. Published by Elsevier Inc. All rights reserved.

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Auteurs

Wolfgang Bothe (W)

Department of Cardiovascular Surgery, Heart Center Freiburg-Bad Krozingen, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, Calif.

Tomasz A Timek (TA)

Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, Calif; Division of Cardiothoracic Surgery Spectrum Health, Grand Rapids, Mich.

Frederick A Tibayan (FA)

Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, Calif; Department of Cardiothoracic Surgery, Oregon Health and Science University, Portland, Ore.

Mario Walther (M)

Department of Mathematics and Applied Statistics, University of Applied Sciences, Jena, Germany.

George T Daughters (GT)

Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, Calif.

Neil B Ingels (NB)

Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, Calif; Laboratory of Cardiovascular Physiology and Biophysics, Research Institute of the Palo Alto Medical Foundation, Palo Alto, Calif.

D Craig Miller (DC)

Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, Calif. Electronic address: dcm@stanford.edu.

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Classifications MeSH

questionsmedicales.fr › Régions du corps › Repères anatomiques › Characterization of 3-dimensional papillary...
questionsmedicales.fr › Eucaryotes › Animaux › Characterization of 3-dimensional papillary...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Characterization of 3-dimensional papillary...
questionsmedicales.fr › Équipement et fournitures › Équipement et fournitures pour les applications des radiations › Marques de positionnement › Characterization of 3-dimensional papillary...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Radiographie › Radioscopie › Characterization of 3-dimensional papillary...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Traitement d'image par ordinateur › Imagerie tridimensionnelle › Characterization of 3-dimensional papillary...
questionsmedicales.fr › Système cardiovasculaire › Coeur › Valves cardiaques › Valve atrioventriculaire gauche › Characterization of 3-dimensional papillary...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Valvulopathies › Insuffisance mitrale › Characterization of 3-dimensional papillary...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus du myocarde › Characterization of 3-dimensional papillary...
questionsmedicales.fr › Système cardiovasculaire › Coeur › Muscles papillaires › Characterization of 3-dimensional papillary...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Méthodologie en recherche épidémiologique › Valeur prédictive des tests › Characterization of 3-dimensional papillary...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Ovis › Ovis aries › Characterization of 3-dimensional papillary...