Otilonium and pinaverium trigger mitochondrial-mediated apoptosis in rat embryo cortical neurons in vitro.
Animals
Apoptosis
/ drug effects
Cattle
Cell Line, Tumor
Cell Survival
/ drug effects
Cells, Cultured
Cerebral Cortex
/ drug effects
Dose-Response Relationship, Drug
Embryo, Mammalian
Female
Humans
Mitochondria
/ drug effects
Morpholines
/ toxicity
Muscarinic Antagonists
Neurons
/ drug effects
Pregnancy
Quaternary Ammonium Compounds
/ toxicity
Rats
Rats, Sprague-Dawley
Apoptosis
Cortical neurons
Mitochondria
Otilonium
Pinaverium
Journal
Neurotoxicology
ISSN: 1872-9711
Titre abrégé: Neurotoxicology
Pays: Netherlands
ID NLM: 7905589
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
20
07
2018
revised:
06
11
2018
accepted:
06
11
2018
pubmed:
19
11
2018
medline:
19
3
2019
entrez:
19
11
2018
Statut:
ppublish
Résumé
In the frame of a repositioning programme with cholinergic medicines in clinical use searching for neuroprotective properties, we surprisingly found that spasmolytic antimuscarinics otilonium and pinaverium exhibited neurotoxic effects in neuronal cultures. We decided to characterize such unexpected action in primary cultures of rat embryo cortical neurons. Neurotoxicity was time- and concentration-dependent, exhibiting approximate EC
Identifiants
pubmed: 30448301
pii: S0161-813X(18)30289-4
doi: 10.1016/j.neuro.2018.11.003
pii:
doi:
Substances chimiques
Morpholines
0
Muscarinic Antagonists
0
Quaternary Ammonium Compounds
0
octylonium
26095-59-0
pinaverium
U2368VVE7O
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
99-111Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.