Surface functionalization of polylactic acid fibers with alendronate groups does not improve the mechanical properties of fiber-reinforced calcium phosphate cements.

Aldehydes / chemistry Alendronate / chemistry Biocompatible Materials / chemistry Bone Cements / chemistry Calcium Phosphates / chemistry Durapatite / chemistry Materials Testing Mechanical Phenomena Polyesters / chemistry Surface Properties
Affinity Alendronate Calcium phosphate cements Polyester Reinforcement

Journal

Journal of the mechanical behavior of biomedical materials
ISSN: 1878-0180
Titre abrégé: J Mech Behav Biomed Mater
Pays: Netherlands
ID NLM: 101322406

Informations de publication

Date de publication:
02 2019
Historique:
received: 15 07 2018
revised: 01 11 2018
accepted: 02 11 2018
pubmed: 19 11 2018
medline: 13 2 2020
entrez: 19 11 2018
Statut: ppublish

Résumé

Calcium phosphate cements (CPCs) are frequently used as synthetic bone substitute, but their intrinsic low fracture toughness impedes their application in highly loaded skeletal sites. However, fibers can be used to reduce the brittleness of these CPCs provided that the affinity between the fibers and cement matrix facilitates the transfer of loads from the matrix to the fibers. The aim of the present work was to improve the interface between hydrophobic polylactic acid (PLA) microfibers and hydrophilic CPC. To this end, calcium-binding alendronate groups were conjugated onto the surface of PLA microfibers via different strategies to immobilize a tunable amount of alendronate onto the fiber surface. CPCs reinforced with PLA fibers revealed toughness values which were up to 50-fold higher than unreinforced CPCs. Nevertheless, surface functionalization of PLA microfibers with alendronate groups did not improve the mechanical properties of fiber-reinforced CPCs.

Identifiants

DOI: 10.1016/j.jmbbm.2018.11.003 PMID: 30448561
pubmed: 30448561
pii: S1751-6161(18)31031-2
doi: 10.1016/j.jmbbm.2018.11.003
pii:
doi:

Substances chimiques

Aldehydes 0
Biocompatible Materials 0
Bone Cements 0
Calcium Phosphates 0
Polyesters 0
poly(lactide) 459TN2L5F5
Durapatite 91D9GV0Z28
calcium phosphate 97Z1WI3NDX
Alendronate X1J18R4W8P

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

472-483

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

Auteurs

Daniela-Geta Petre (DG)

Department of Regenerative Biomaterials, Radboud University Medical Center, Philips van Leydenlaan 25, Nijmegen 6525 EX, the Netherlands. Electronic address: daniela-geta.petre@radboudumc.nl.

Nathan W Kucko (NW)

Department of Regenerative Biomaterials, Radboud University Medical Center, Philips van Leydenlaan 25, Nijmegen 6525 EX, the Netherlands; CAM Bioceramics B. V., Zernikedreef 6, Leiden 2333 CL, the Netherlands.

Anna Abbadessa (A)

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, Utrecht 3508 TB, the Netherlands; Department of Fibre and Polymer Technology, School of Engineering Sciences in Chemistry, Biotechnology and Health, Royal Institute of Technology, KTH, Teknikringen 56-58, 10044 Stockholm, Sweden.

Tina Vermonden (T)

Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, Utrecht 3508 TB, the Netherlands.

Alessandro Polini (A)

Department of Regenerative Biomaterials, Radboud University Medical Center, Philips van Leydenlaan 25, Nijmegen 6525 EX, the Netherlands.

Sander C G Leeuwenburgh (SCG)

Department of Regenerative Biomaterials, Radboud University Medical Center, Philips van Leydenlaan 25, Nijmegen 6525 EX, the Netherlands. Electronic address: sander.leeuwenburgh@radboudumc.nl.

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Aldéhydes › Surface functionalization of polylactic acid...
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Phosphonates › Diphosphonates › Alendronate › Surface functionalization of polylactic acid...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Matériaux biocompatibles › Surface functionalization of polylactic acid...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Matières plastiques › Résines synthétiques › Ciments osseux › Surface functionalization of polylactic acid...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › Phosphates › Phosphates de calcium › Surface functionalization of polylactic acid...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › Phosphates › Phosphates de calcium › Apatites › Hydroxyapatites › Durapatite › Surface functionalization of polylactic acid...
questionsmedicales.fr › Techniques d'investigation › Test de matériaux › Surface functionalization of polylactic acid...
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Surface functionalization of polylactic acid...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyesters › Surface functionalization of polylactic acid...
questionsmedicales.fr › Phénomènes chimiques › Propriétés de surface › Surface functionalization of polylactic acid...