Endometrial carcinoma: Evaluation using diffusion-tensor imaging and its correlation with histopathologic findings.
MR imaging
diffusion-tensor imaging
diffusion-weighted imaging
endometrial carcinoma
uterus
Journal
Journal of magnetic resonance imaging : JMRI
ISSN: 1522-2586
Titre abrégé: J Magn Reson Imaging
Pays: United States
ID NLM: 9105850
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
07
09
2018
revised:
15
10
2018
accepted:
16
10
2018
pubmed:
20
11
2018
medline:
15
8
2020
entrez:
20
11
2018
Statut:
ppublish
Résumé
Although the prognosis of endometrial carcinoma (EMC) patients strictly depends on tumor invasion depth and its histologic grade, accurate preoperative assessment of these prognostic factors is often difficult. To determine the usefulness of diffusion-tensor imaging (DTI) as a noninvasive method for evaluating tumor invasion depth and its histologic grade in patients with EMC. Prospective. Twenty-five consecutive patients with histologically confirmed EMC who were surgically treated at our institution. DTI was performed with a 1.5T MRI system using a single-shot echo-planar imaging sequence with b values of 0 and 1000 s/mm Fractional anisotropy (FA), mean diffusivity (MD), and axial diffusivity (AD) maps were analyzed by three observers and compared with histopathologic findings. Dunnett's test, Spearman's rank correlation coefficient, and receiver operating characteristic (ROC) curve analyses. FA maps from all patients distinctly identified the junctional zone as a high-FA zone (0.864 ± 0.037) that was significantly different from the endometrium and outer myometrium (0.251 ± 0.030 and 0.471 ± 0.091, respectively; P < 0.001). All EMCs were clearly depicted as hypointense areas on all DTI maps. AD maps provided the best tumor-to-uterus contrast, and EMCs (0.977 ± 0.120 × 10 In patients with EMC, DTI may be useful for evaluating tumor invasion depth and its histologic grade. 1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:250-260.
Sections du résumé
BACKGROUND
Although the prognosis of endometrial carcinoma (EMC) patients strictly depends on tumor invasion depth and its histologic grade, accurate preoperative assessment of these prognostic factors is often difficult.
PURPOSE
To determine the usefulness of diffusion-tensor imaging (DTI) as a noninvasive method for evaluating tumor invasion depth and its histologic grade in patients with EMC.
STUDY TYPE
Prospective.
POPULATION
Twenty-five consecutive patients with histologically confirmed EMC who were surgically treated at our institution.
FIELD STRENGTH/SEQUENCE
DTI was performed with a 1.5T MRI system using a single-shot echo-planar imaging sequence with b values of 0 and 1000 s/mm
ASSESSMENT
Fractional anisotropy (FA), mean diffusivity (MD), and axial diffusivity (AD) maps were analyzed by three observers and compared with histopathologic findings.
STATISTICAL TESTS
Dunnett's test, Spearman's rank correlation coefficient, and receiver operating characteristic (ROC) curve analyses.
RESULTS
FA maps from all patients distinctly identified the junctional zone as a high-FA zone (0.864 ± 0.037) that was significantly different from the endometrium and outer myometrium (0.251 ± 0.030 and 0.471 ± 0.091, respectively; P < 0.001). All EMCs were clearly depicted as hypointense areas on all DTI maps. AD maps provided the best tumor-to-uterus contrast, and EMCs (0.977 ± 0.120 × 10
DATA CONCLUSION
In patients with EMC, DTI may be useful for evaluating tumor invasion depth and its histologic grade.
LEVEL OF EVIDENCE
1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:250-260.
Substances chimiques
Contrast Media
0
Organometallic Compounds
0
gadobutrol
1BJ477IO2L
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
250-260Informations de copyright
© 2018 International Society for Magnetic Resonance in Medicine.