LC-MS-guided isolation of anti-inflammatory 2-(2-phenylethyl)chromone dimers from Chinese agarwood (Aquilaria sinensis).
Animals
Anti-Inflammatory Agents, Non-Steroidal
/ chemistry
Chromatography, Liquid
Chromones
/ chemistry
Dimerization
Drug Evaluation, Preclinical
/ methods
Inhibitory Concentration 50
Lipopolysaccharides
/ pharmacology
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Nitric Oxide
/ antagonists & inhibitors
Plants, Medicinal
/ chemistry
RAW 264.7 Cells
Spectrometry, Mass, Electrospray Ionization
Thymelaeaceae
/ chemistry
2-(2-Phenylethyl)chromone dimer
Anti-inflammatory activity
Aquilaria sinensis (Lour.) Spreng
Aquisinenone
Chinese agarwood
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
29
08
2018
revised:
04
11
2018
accepted:
05
11
2018
pubmed:
20
11
2018
medline:
23
1
2019
entrez:
20
11
2018
Statut:
ppublish
Résumé
Fifteen previously undescribed 2-(2-phenylethyl)chromone dimers, along with two known analogues were isolated from Chinese agarwood (Aquilaria sinensis) by a LC-MS-guided fractionation procedure. Their structures were elucidated on the basis of spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS). The isolated compounds exhibited significant inhibition of nitric oxide production in lipopolysaccharide-stimulated RAW264.7 cells with IC
Identifiants
pubmed: 30453219
pii: S0031-9422(18)30505-3
doi: 10.1016/j.phytochem.2018.11.003
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents, Non-Steroidal
0
Chromones
0
Lipopolysaccharides
0
Nitric Oxide
31C4KY9ESH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
46-55Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.