Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein.
Animals
Antibodies, Monoclonal
/ immunology
Antibodies, Neutralizing
/ immunology
Antibodies, Viral
/ immunology
Chlorocebus aethiops
Cricetinae
Encephalitis Virus, Eastern Equine
/ immunology
Encephalomyelitis, Equine
/ immunology
Epitope Mapping
Epitopes
/ immunology
Female
HEK293 Cells
Humans
Mice
Protein Domains
/ immunology
Vero Cells
Viral Envelope Proteins
/ immunology
Journal
Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
27
05
2018
accepted:
10
10
2018
pubmed:
21
11
2018
medline:
18
6
2019
entrez:
21
11
2018
Statut:
ppublish
Résumé
Eastern equine encephalitis virus (EEEV) is a mosquito-transmitted alphavirus with a high case mortality rate in humans. EEEV is a biodefence concern because of its potential for aerosol spread and the lack of existing countermeasures. Here, we identify a panel of 18 neutralizing murine monoclonal antibodies (mAbs) against the EEEV E2 glycoprotein, several of which have 'elite' activity with 50 and 99% effective inhibitory concentrations (EC
Identifiants
pubmed: 30455470
doi: 10.1038/s41564-018-0286-4
pii: 10.1038/s41564-018-0286-4
pmc: PMC6294662
mid: NIHMS1509440
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antibodies, Neutralizing
0
Antibodies, Viral
0
Epitopes
0
Viral Envelope Proteins
0
glycoprotein E2, equine encephalitis virus
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
187-197Subventions
Organisme : NIH HHS
ID : P51 OD011092
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI095436
Pays : United States
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