The effect of PPARγ inhibition on bone marrow adipose tissue and bone in C3H/HeJ mice.
Adipocytes
/ drug effects
Adipose Tissue
/ drug effects
Anilides
/ pharmacology
Animals
Bone Marrow
/ drug effects
Bone Remodeling
/ drug effects
Cell Count
Cell Size
Female
Humans
Mice
Mice, Inbred C3H
Organ Size
Osteoporosis, Postmenopausal
Ovariectomy
PPAR gamma
/ antagonists & inhibitors
Tibia
/ diagnostic imaging
Tomography, X-Ray Computed
C3H/HeJ mice
PPARγ antagonist
bone marrow adipose tissue
bone turnover
ovariectomy
Journal
American journal of physiology. Endocrinology and metabolism
ISSN: 1522-1555
Titre abrégé: Am J Physiol Endocrinol Metab
Pays: United States
ID NLM: 100901226
Informations de publication
Date de publication:
01 01 2019
01 01 2019
Historique:
pubmed:
21
11
2018
medline:
22
11
2019
entrez:
21
11
2018
Statut:
ppublish
Résumé
Bone marrow adipose tissue (BMAT) increases after menopause, and increased BMAT is associated with osteoporosis and prevalent vertebral fractures. Peroxisome proliferator-activated receptor-γ (PPARγ) activation promotes adipogenesis and inhibits osteoblastogenesis; therefore, PPARγ is a potential contributor to the postmenopausal increase in BMAT and decrease in bone mass. The aim of this study is to determine if PPARγ inhibition can prevent ovariectomy-induced BMAT increase and bone loss in C3H/HeJ mice. Fourteen-week-old female C3H/HeJ mice ( n = 40) were allocated to four intervention groups: sham surgery (Sham) or ovariectomy (OVX; isoflurane anesthesia) with either vehicle (Veh) or PPARγ antagonist administration (GW9662; 1 mg·kg
Identifiants
pubmed: 30457914
doi: 10.1152/ajpendo.00265.2018
doi:
Substances chimiques
2-chloro-5-nitrobenzanilide
0
Anilides
0
PPAR gamma
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM