A colorimetric paper sensor for citrate as biomarker for early stage detection of prostate cancer based on peroxidase-like activity of cysteine-capped gold nanoclusters.
Biomarkers, Tumor
/ urine
Citric Acid
/ analysis
Colorimetry
/ instrumentation
Cysteine
/ chemistry
Gold
/ chemistry
Humans
Lab-On-A-Chip Devices
Limit of Detection
Male
Microscopy, Electron, Transmission
Nanostructures
/ chemistry
Paper
Peroxidase
/ metabolism
Prostatic Neoplasms
/ diagnosis
Spectrometry, Fluorescence
Biomarker
Citrate
Gold nanoclusters
Paper based
Journal
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
ISSN: 1873-3557
Titre abrégé: Spectrochim Acta A Mol Biomol Spectrosc
Pays: England
ID NLM: 9602533
Informations de publication
Date de publication:
05 Mar 2019
05 Mar 2019
Historique:
received:
05
08
2018
revised:
30
10
2018
accepted:
12
11
2018
pubmed:
21
11
2018
medline:
1
2
2019
entrez:
21
11
2018
Statut:
ppublish
Résumé
Citrate is currently considered a preferred biomarker for the early stage detection of prostate cancer. In the present work, based on the highly efficient catalytic properties of gold nanoclusters, a novel system for optical determination of citrate was successfully established under optimized conditions. Cysteine-capped gold nanoclusters (Cys-AuNCs) are shown to have an intrinsic peroxidase-mimetic activity. In the presence of H
Identifiants
pubmed: 30458393
pii: S1386-1425(18)31023-0
doi: 10.1016/j.saa.2018.11.026
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Citric Acid
2968PHW8QP
Gold
7440-57-5
Peroxidase
EC 1.11.1.7
Cysteine
K848JZ4886
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
251-259Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.