Inhibition of CYP2E1 attenuates myocardial dysfunction in a murine model of insulin resistance through NLRP3-mediated regulation of mitophagy.

Animals Autophagy Cardiomyopathies / metabolism Cytochrome P-450 CYP2E1 / drug effects Cytochrome P-450 CYP2E1 Inhibitors / pharmacology Disease Models, Animal Inflammasomes / metabolism Insulin Resistance / physiology Male Mice Mice, Knockout Mitochondria / metabolism Mitophagy / physiology Myocardial Contraction Myocardium / metabolism Myocytes, Cardiac / metabolism NLR Family, Pyrin Domain-Containing 3 Protein / metabolism Nitric Oxide Synthase Type II / metabolism Oxidative Stress Proto-Oncogene Proteins c-akt / genetics Signal Transduction
CYP2E1 Cardiac function Insulin resistance Mitophagy NLRP3 iNOS

Journal

Biochimica et biophysica acta. Molecular basis of disease
ISSN: 1879-260X
Titre abrégé: Biochim Biophys Acta Mol Basis Dis
Pays: Netherlands
ID NLM: 101731730

Informations de publication

Date de publication:
01 2019
Historique:
received: 28 04 2018
revised: 02 08 2018
accepted: 10 08 2018
entrez: 23 11 2018
pubmed: 23 11 2018
medline: 14 8 2019
Statut: ppublish

Résumé

Insulin resistance leads to myocardial contractile dysfunction and deranged autophagy although the underlying mechanism or targeted therapeutic strategy is still lacking. This study was designed to examine the impact of inhibition of the cytochrome P450 2E1 (CYP2E1) enzyme on myocardial function and mitochondrial autophagy (mitophagy) in an Akt2 knockout model of insulin resistance. Adult wild-type (WT) and Akt2

Identifiants

DOI: 10.1016/j.bbadis.2018.08.017 PMID: 30463689
pubmed: 30463689
pii: S0925-4439(18)30302-8
doi: 10.1016/j.bbadis.2018.08.017
pii:
doi:

Substances chimiques

Cytochrome P-450 CYP2E1 Inhibitors 0
Inflammasomes 0
NLR Family, Pyrin Domain-Containing 3 Protein 0
Nlrp3 protein, mouse 0
Cytochrome P-450 CYP2E1 EC 1.14.13.-
cytochrome P-450 2E1, mouse EC 1.14.13.-
Nitric Oxide Synthase Type II EC 1.14.13.39
Nos2 protein, mouse EC 1.14.13.39
Akt2 protein, mouse EC 2.7.11.1
Proto-Oncogene Proteins c-akt EC 2.7.11.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

206-217

Informations de copyright

Copyright © 2018 Elsevier B.V. All rights reserved.

Auteurs

Jun Ren (J)

Department of Cardiology, Zhongshan Hospital Fudan University, Shanghai 210032, China; Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA. Electronic address: jren@uwyo.edu.

Zhaohui Pei (Z)

The Second Department of Cardiology, The Third Hospital of Nanchang, Nanchang, Jiangxi 330009, China.

Xiyao Chen (X)

Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA.

Melissa J Berg (MJ)

Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA.

Khalid Matrougui (K)

Department of Physiology, Eastern Virginia School of Medicine, Norfolk, VA, USA.

Qing-Hua Zhang (QH)

Department of Obstetrics and Gynecology, Daping Hospital, Third Military Medical University, Chongqing 400038, China. Electronic address: zhangqh1123@163.com.

Yingmei Zhang (Y)

Department of Cardiology, Zhongshan Hospital Fudan University, Shanghai 210032, China; Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA. Electronic address: zhangym197951@126.com.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Inhibition of CYP2E1 attenuates myocardial...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › Inhibition of CYP2E1 attenuates myocardial...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Cardiomyopathies › Inhibition of CYP2E1 attenuates myocardial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Hémoprotéines › Cytochromes › Cytochrome P-450 enzyme system › Famille-2 de cytochromes P450 › Cytochrome P-450 CYP2E1 › Inhibition of CYP2E1 attenuates myocardial...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs des enzymes du cytochrome P-450 › Inhibiteurs du cytochrome P-450 CYP2E1 › Inhibition of CYP2E1 attenuates myocardial...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Inhibition of CYP2E1 attenuates myocardial...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Inflammasomes › Inhibition of CYP2E1 attenuates myocardial...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Insulinorésistance › Inhibition of CYP2E1 attenuates myocardial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Inhibition of CYP2E1 attenuates myocardial...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Inhibition of CYP2E1 attenuates myocardial...
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Mitochondries › Inhibition of CYP2E1 attenuates myocardial...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Renouvellement des mitochondries › Dégradation des mitochondries › Inhibition of CYP2E1 attenuates myocardial...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Contraction musculaire › Contraction myocardique › Inhibition of CYP2E1 attenuates myocardial...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Myocarde › Inhibition of CYP2E1 attenuates myocardial...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Inhibition of CYP2E1 attenuates myocardial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Protéines NLR › Protéine-3 de la famille des NLR contenant un domaine pyrine › Inhibition of CYP2E1 attenuates myocardial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines nucléaires › Protéines liant le poly-adp-ribose › Nitric oxide synthase type II › Inhibition of CYP2E1 attenuates myocardial...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Inhibition of CYP2E1 attenuates myocardial...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-akt › Inhibition of CYP2E1 attenuates myocardial...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Inhibition of CYP2E1 attenuates myocardial...