Novel positioning from obesity to cancer: FTO, an m
3' Untranslated Regions
Adenosine
/ analogs & derivatives
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
/ genetics
Body Mass Index
Cell Proliferation
/ genetics
Demethylation
Disease Progression
Drug Resistance, Neoplasm
/ genetics
Epigenesis, Genetic
Gene Expression Regulation
Humans
Neoplasm Metastasis
/ genetics
Neoplasms
/ drug therapy
Obesity
/ genetics
Oncogenes
Polymorphism, Single Nucleotide
Prognosis
Radiation Tolerance
/ genetics
Chemo-radiotherapy resistance
FTO
M6A RNA demethylase
Oncogene
Proliferation
Tumourigenesis
Journal
Journal of cancer research and clinical oncology
ISSN: 1432-1335
Titre abrégé: J Cancer Res Clin Oncol
Pays: Germany
ID NLM: 7902060
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
23
06
2018
accepted:
13
11
2018
pubmed:
23
11
2018
medline:
29
1
2019
entrez:
23
11
2018
Statut:
ppublish
Résumé
The fat mass- and obesity-associated (FTO) gene on chromosome 16q12.2 shows an intimate association with obesity and body mass index. Recently, research into the FTO gene and its expression product has attracted widespread interest due to the identification of FTO as an N6-methyladenosine (m6A) demethylase. FTO primarily regulates the m6A levels of downstream targets via their 3' untranslated regions. FTO not only plays a critical role in obesity-related diseases but also is involved in the occurrence, development and prognosis of many types of cancer, such as acute myeloid leukaemia, glioblastoma and breast cancer. Currently, studies indicate that FTO is a crucial component of m6A modification, it regulates cancer stem cell function, and promotes the growth, self-renewal and metastasis of cancer cells. In this review, we summarized and analysed the data regarding the structural features and biological functions of FTO as well as its association with different cancers and possible molecular mechanisms. We systematically reviewed the related literatures regarding FTO and its demethylation activity in many pathologic and physiological processes, especially in cancer-related diseases based on PubMed databases in this article. Mounting evidence indicated that FTO plays a critical role in occurrence, progression and treatment of various cancers, even acting as a cancer oncogene in acute myeloid leukaemia, research on which is no longer restricted to metabolic diseases such as obesity and diabetes. Considering FTO's critical role in many diseases, FTO may become a new promising target for the diagnosis and treatment of various diseases in the near future, especially for specific types of cancers, such as acute myeloid leukaemia, glioblastoma and breast cancer.
Identifiants
pubmed: 30465076
doi: 10.1007/s00432-018-2796-0
pii: 10.1007/s00432-018-2796-0
doi:
Substances chimiques
3' Untranslated Regions
0
N-methyladenosine
CLE6G00625
Alpha-Ketoglutarate-Dependent Dioxygenase FTO
EC 1.14.11.33
FTO protein, human
EC 1.14.11.33
Adenosine
K72T3FS567
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
19-29Subventions
Organisme : National Natural Science Foundation of China
ID : 31201028
Organisme : National Natural Science Foundation of China
ID : 81872893
Organisme : Fundamental Research Fund for the Central Universities
ID : 21617462
Organisme : Guangzhou Science Technology and Innovation Commission
ID : 201707010099
Organisme : Provincial Undergraduates' Innovation and Entrepreneurship Training Programs
ID : 82618257
Organisme : Medical Scientific Research Foundation of Guangdong Province
ID : A2017574
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