Human Stimulus Factor Is a Promising Peptide for Delivery of Therapeutics.
Administration, Inhalation
Asthma
/ drug therapy
Bronchodilator Agents
/ administration & dosage
Cell Line, Tumor
Cell Membrane
/ drug effects
Drug Carriers
/ chemistry
Drug Combinations
Fluticasone
/ administration & dosage
Humans
Lactoferrin
/ chemistry
Peptides
/ chemistry
Permeability
/ drug effects
Protein Domains
Pulmonary Disease, Chronic Obstructive
/ drug therapy
Respiratory Mucosa
/ cytology
Salmeterol Xinafoate
/ administration & dosage
cell transport
cell-penetrating peptide
corticosteroids
human stimulus factor
inhaler
Journal
Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
24
09
2018
revised:
24
10
2018
accepted:
14
11
2018
pubmed:
23
11
2018
medline:
28
5
2020
entrez:
23
11
2018
Statut:
ppublish
Résumé
Fluticasone propionate uptake in the presence of a proprietary cell-penetrating peptide (human stimulus factor, [HSF]) based on the N-terminal domain of lactoferrin was studied, alone and in combination with salmeterol, using an air interface Calu-3 epithelial model. The HSF enhanced uptake and transport of fluticasone propionate across the epithelial barrier when alone and in presence of salmeterol. This was attributed to transcellular-mediated uptake. This HSF is a promising peptide for delivery of therapeutics where enhanced epithelial penetrating is required.
Identifiants
pubmed: 30465781
pii: S0022-3549(18)30721-4
doi: 10.1016/j.xphs.2018.11.017
pii:
doi:
Substances chimiques
Bronchodilator Agents
0
Drug Carriers
0
Drug Combinations
0
LTF protein, human
0
Peptides
0
Salmeterol Xinafoate
6EW8Q962A5
Fluticasone
CUT2W21N7U
Lactoferrin
EC 3.4.21.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1401-1403Informations de copyright
Copyright © 2019 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.