Thymol exposure mediates pro-oxidant shift by regulating Nrf2 and apoptotic events in zebrafish (Danio rerio) embryos.

Animals Apoptosis / drug effects Embryo, Nonmammalian / drug effects NF-E2-Related Factor 2 / metabolism Reactive Oxygen Species / metabolism Thymol / pharmacology Zebrafish / embryology Zebrafish Proteins / metabolism
Thymol antioxidants apoptosis developmental toxicity reactive oxygen species zebrafish

Journal

Environmental toxicology and pharmacology
ISSN: 1872-7077
Titre abrégé: Environ Toxicol Pharmacol
Pays: Netherlands
ID NLM: 9612020

Informations de publication

Date de publication:
Jan 2019
Historique:
received: 29 11 2017
revised: 14 07 2018
accepted: 05 11 2018
pubmed: 23 11 2018
medline: 14 2 2019
entrez: 23 11 2018
Statut: ppublish

Résumé

The biochemical process of oxidative stress is an integral mechanism of chemical toxicity, contributing to complex pathological disorders. Thymol (THY) has a wide range of therapeutic applications for several ailments, although a better understanding of signaling cues regulated by this compound is needed to address the mechanism of its action. To better perceive the mode of action, we investigated the potential impact of THY on zebrafish embryos, with special emphasis on ROS biogenesis. In this study, we exposed the zebrafish embryos to 25, 50 and 100μM of THY for 96 hours post fertilization (hpf). Noticeable teratogenic effects were observed upon assessing the survival rate (LC

Identifiants

DOI: 10.1016/j.etap.2018.11.001 PMID: 30466008
pubmed: 30466008
pii: S1382-6689(18)30550-7
doi: 10.1016/j.etap.2018.11.001
pii:
doi:

Substances chimiques

NF-E2-Related Factor 2 0
Reactive Oxygen Species 0
Zebrafish Proteins 0
Thymol 3J50XA376E

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-8

Informations de copyright

Copyright © 2018 Elsevier B.V. All rights reserved.

Auteurs

Manigandan Krishnan (M)

Department of Biotechnology, College of Engineering, Daegu University Kyoungsan, Kyoungbook 712-714, Republic of Korea. Electronic address: biomani1@gmail.com.

Dae Kwang Kim (DK)

Department of Medical Genetics, School of Medicine, Keimyung University, Dalseo-Gu, Daegu, Republic of Korea. Electronic address: dkkimmd@kmu.ac.kr.

Se Gie Kim (S)

Department of Pharmaceutical Science and Technology, Catholic University of Daegu, Kyungsan City, Kyungbouk, Republic of Korea. Electronic address: sgkim7@cu.ac.kr.

Sun Chul Kang (SC)

Department of Biotechnology, College of Engineering, Daegu University Kyoungsan, Kyoungbook 712-714, Republic of Korea. Electronic address: sckang@daegu.ac.kr.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Thymol exposure mediates pro-oxidant shift by...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Thymol exposure mediates pro-oxidant shift by...
questionsmedicales.fr › Structures de l'embryon › Embryon non mammalien › Thymol exposure mediates pro-oxidant shift by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteur-2 apparenté à NF-E2 › Thymol exposure mediates pro-oxidant shift by...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Thymol exposure mediates pro-oxidant shift by...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Terpènes › Monoterpènes › Thymol › Thymol exposure mediates pro-oxidant shift by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Thymol exposure mediates pro-oxidant shift by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de poisson › Protéines de poisson-zèbre › Thymol exposure mediates pro-oxidant shift by...