Atopic dermatitis at preschool age and contact allergy in adolescence: a population-based cohort study.
Journal
The British journal of dermatology
ISSN: 1365-2133
Titre abrégé: Br J Dermatol
Pays: England
ID NLM: 0004041
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
accepted:
19
11
2018
pubmed:
24
11
2018
medline:
21
4
2020
entrez:
24
11
2018
Statut:
ppublish
Résumé
Atopic dermatitis (AD) is characterized by an impaired skin barrier, which can allow enhanced penetration of allergens. It is not clear whether AD influences the risk of developing contact allergy. To examine the association between AD at preschool age and contact allergy at 16 years of age. At 16 years of age, 2215 adolescents from the population-based cohort BAMSE were included. These adolescents had been followed with repeated questionnaires regarding AD throughout childhood, and contact allergy was assessed by skin patch test at 16 years. AD at preschool age was associated with contact allergy to at least one of the tested substances at 16 years of age among boys [adjusted odds ratio (OR) 1·51, 95% confidence interval (CI) 1·03-2·20] but not among girls (adjusted OR 0·77, 95% CI 0·54-1·10). AD at preschool age was not associated with contact allergy to nickel in either boys or girls. In contrast, AD at preschool age was associated with contact allergy to fragrance mix I (adjusted OR 3·10, 95% CI 1·66-5·80). This association was observed especially for AD at preschool age in combination with IgE sensitization to airborne or food allergens (adjusted OR 3·80, 95% CI 1·67-8·61). The results suggest that AD in early childhood may be associated with contact allergy to fragrances, but not to nickel, in adolescence.
Sections du résumé
BACKGROUND
Atopic dermatitis (AD) is characterized by an impaired skin barrier, which can allow enhanced penetration of allergens. It is not clear whether AD influences the risk of developing contact allergy.
OBJECTIVES
To examine the association between AD at preschool age and contact allergy at 16 years of age.
METHODS
At 16 years of age, 2215 adolescents from the population-based cohort BAMSE were included. These adolescents had been followed with repeated questionnaires regarding AD throughout childhood, and contact allergy was assessed by skin patch test at 16 years.
RESULTS
AD at preschool age was associated with contact allergy to at least one of the tested substances at 16 years of age among boys [adjusted odds ratio (OR) 1·51, 95% confidence interval (CI) 1·03-2·20] but not among girls (adjusted OR 0·77, 95% CI 0·54-1·10). AD at preschool age was not associated with contact allergy to nickel in either boys or girls. In contrast, AD at preschool age was associated with contact allergy to fragrance mix I (adjusted OR 3·10, 95% CI 1·66-5·80). This association was observed especially for AD at preschool age in combination with IgE sensitization to airborne or food allergens (adjusted OR 3·80, 95% CI 1·67-8·61).
CONCLUSIONS
The results suggest that AD in early childhood may be associated with contact allergy to fragrances, but not to nickel, in adolescence.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
782-789Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2018 British Association of Dermatologists.