Suppressing effect of CMPPE, a new positive allosteric modulator of the GABA

Alcohol Drinking / prevention & control Allosteric Regulation / drug effects Animals Dose-Response Relationship, Drug Ethanol / administration & dosage Female GABA Modulators / therapeutic use GABA-B Receptor Agonists / therapeutic use Male Pyrazoles / therapeutic use Pyrimidines / therapeutic use Rats Rats, Wistar Receptors, GABA-B / physiology Self Administration Treatment Outcome
Alcohol self-administration CMPPE GABA(B) receptor Positive allosteric modulator Rat

Journal

Alcohol (Fayetteville, N.Y.)
ISSN: 1873-6823
Titre abrégé: Alcohol
Pays: United States
ID NLM: 8502311

Informations de publication

Date de publication:
03 2019
Historique:
received: 21 03 2018
revised: 18 05 2018
accepted: 29 05 2018
pubmed: 24 11 2018
medline: 27 3 2020
entrez: 24 11 2018
Statut: ppublish

Résumé

Positive allosteric modulators (PAMs) of the GABA

Identifiants

DOI: 10.1016/j.alcohol.2018.05.015 PMID: 30468987
pubmed: 30468987
pii: S0741-8329(18)30081-8
doi: 10.1016/j.alcohol.2018.05.015
pii:
doi:

Substances chimiques

2-(1-(2-(4-chlorophenyl)-5-methylpyrazolo(1,5-a)pyrimidin-7-yl)-2-piperidinyl)ethanol 0
GABA Modulators 0
GABA-B Receptor Agonists 0
Pyrazoles 0
Pyrimidines 0
Receptors, GABA-B 0
Ethanol 3K9958V90M

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

79-87

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Paola Maccioni (P)

Neuroscience Institute, Section of Cagliari, National Research Council of Italy, I-09042 Monserrato, CA, Italy.

Federica Fara (F)

Neuroscience Institute, Section of Cagliari, National Research Council of Italy, I-09042 Monserrato, CA, Italy.

Irene Lorrai (I)

Neuroscience Institute, Section of Cagliari, National Research Council of Italy, I-09042 Monserrato, CA, Italy; Department of Biomedical Sciences, University of Cagliari, I-09042 Monserrato, CA, Italy.

Carla Acciaro (C)

Neuroscience Institute, Section of Cagliari, National Research Council of Italy, I-09042 Monserrato, CA, Italy.

Claudia Mugnaini (C)

Department of Biotechnology, Chemistry, and Pharmacy, University of Siena, I-53100 Siena, SI, Italy.

Federico Corelli (F)

Department of Biotechnology, Chemistry, and Pharmacy, University of Siena, I-53100 Siena, SI, Italy.

Giancarlo Colombo (G)

Neuroscience Institute, Section of Cagliari, National Research Council of Italy, I-09042 Monserrato, CA, Italy. Electronic address: colomb@unica.it.

Articles similaires

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis.

Hiu Yee Liu, Ashley A Eso, Nathan Cook et al.
1.00
Humans Meals Time Factors Female Adult

Classifications MeSH

questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement dipsique › Consommation d'alcool › Suppressing effect of CMPPE, a new positive...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Régulation allostérique › Suppressing effect of CMPPE, a new positive...
questionsmedicales.fr › Eucaryotes › Animaux › Suppressing effect of CMPPE, a new positive...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › Suppressing effect of CMPPE, a new positive...
questionsmedicales.fr › Composés chimiques organiques › Alcools › Éthanol › Suppressing effect of CMPPE, a new positive...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents GABA › Modulateurs GABA › Suppressing effect of CMPPE, a new positive...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents GABA › Agonistes GABA › Agonistes du recepteur GABA-B › Suppressing effect of CMPPE, a new positive...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Pyrazoles › Suppressing effect of CMPPE, a new positive...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Suppressing effect of CMPPE, a new positive...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Suppressing effect of CMPPE, a new positive...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › Suppressing effect of CMPPE, a new positive...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Récepteurs GABA-B › Suppressing effect of CMPPE, a new positive...
questionsmedicales.fr › Thérapeutique › Autoadministration › Suppressing effect of CMPPE, a new positive...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Suppressing effect of CMPPE, a new positive...