Applications of Immunomodulatory Immune Synergies to Adjuvant Discovery and Vaccine Development.
adjuvant
antigen
immune synergy
immunology
vaccine
Journal
Trends in biotechnology
ISSN: 1879-3096
Titre abrégé: Trends Biotechnol
Pays: England
ID NLM: 8310903
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
20
06
2018
revised:
15
10
2018
accepted:
16
10
2018
pubmed:
25
11
2018
medline:
18
12
2019
entrez:
25
11
2018
Statut:
ppublish
Résumé
Pathogens comprise a diverse set of immunostimulatory molecules that activate the innate immune system during infection. The immune system recognizes distinct combinations of pathogenic molecules leading to multiple immune activation events that cooperate to produce enhanced immune responses, known as 'immune synergies'. Effective immune synergies are essential for the clearance of pathogens, thus inspiring novel adjuvant design to improve vaccines. We highlight current vaccine adjuvants and the importance of immune synergies to adjuvant and vaccine design. The focus is on new technologies used to study and apply immune synergies to adjuvant and vaccine development. Finally, we discuss how recent findings can be applied to the future design and characterization of synergistic adjuvants and vaccines.
Identifiants
pubmed: 30470547
pii: S0167-7799(18)30291-9
doi: 10.1016/j.tibtech.2018.10.004
pii:
doi:
Substances chimiques
Adjuvants, Immunologic
0
Vaccines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
373-388Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.