Soluble intercellular adhesion molecule-1 is a prognostic marker in colorectal carcinoma.


Journal

International journal of colorectal disease
ISSN: 1432-1262
Titre abrégé: Int J Colorectal Dis
Pays: Germany
ID NLM: 8607899

Informations de publication

Date de publication:
Feb 2019
Historique:
accepted: 12 11 2018
pubmed: 25 11 2018
medline: 30 4 2019
entrez: 25 11 2018
Statut: ppublish

Résumé

Serological tumor markers are routinely used to monitor tumor onset and progression. In colorectal carcinoma (CRC), the carcinoembryonic antigen (CEA) is roughly elevated in 50% of patients at initial diagnosis. Soluble ICAM-1 (sICAM-1) is elevated in different cancers. The aim of this study was to evaluate the prognostic relevance of sICAM-1 combined with CEA in patients with CRC. In blood samples of 297 CRC patients, sICAM-1 was determined by ELISA and CEA by microparticle enzyme immunoassay the day before oncologic resection. Separation in patients with sICAM-1 Cancer-related 5-year survival rate of patients with sICAM-1 Application of a novel risk score combining CEA/sICAM-1 serum concentrations allows the identification of high-risk groups for poor survival in CRC patients.

Identifiants

pubmed: 30470940
doi: 10.1007/s00384-018-3198-0
pii: 10.1007/s00384-018-3198-0
pmc: PMC6331741
doi:

Substances chimiques

Biomarkers, Tumor 0
Carcinoembryonic Antigen 0
Intercellular Adhesion Molecule-1 126547-89-5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

309-317

Subventions

Organisme : Interdisziplinäres Zentrum für Klinische Forschung
ID : D28
Organisme : Deutsche Forschungsgemeinschaft
ID : FOR 2438
Organisme : Doktor Robert Pfleger Stiftung
ID : AZ

Références

Cardiovasc Res. 1999 Mar;41(3):603-10
pubmed: 10435032
Cancer Res. 1999 Oct 15;59(20):5128-32
pubmed: 10537287
Clin Cancer Res. 2000 Mar;6(3):1175-9
pubmed: 10741749
Eur J Cancer. 2001 Dec;37(18):2392-7
pubmed: 11720833
Eur J Cancer. 2002 Nov;38(17):2252-7
pubmed: 12441261
Am J Gastroenterol. 2003 Feb;98(2):478-85
pubmed: 12591072
J Surg Oncol. 2003 Jul;83(3):180-4
pubmed: 12827689
Wiad Lek. 2003;56(3-4):147-51
pubmed: 12923961
Indian J Cancer. 2001 Mar;38(1):1-7
pubmed: 14758878
Neoplasma. 2004;51(1):34-7
pubmed: 15004657
Carcinogenesis. 2004 Oct;25(10):1925-34
pubmed: 15217903
Eur Cytokine Netw. 2004 Apr-Jun;15(2):91-8
pubmed: 15319166
Rev Med Chil. 2004 Jun;132(6):691-700
pubmed: 15332370
J Surg Res. 2005 Apr;124(2):169-74
pubmed: 15820244
World J Gastroenterol. 2005 Jul 21;11(27):4250-3
pubmed: 16015700
Arch Dermatol Res. 2005 Dec;297(6):256-60
pubmed: 16222535
J Biol Chem. 2006 Feb 10;281(6):3157-64
pubmed: 16332693
Curr Mol Med. 2007 Mar;7(2):219-27
pubmed: 17346172
Eur J Cancer. 2007 Jun;43(9):1348-60
pubmed: 17512720
Folia Histochem Cytobiol. 2009;47(4):621-5
pubmed: 20430730
Coll Antropol. 2012 Dec;36(4):1355-61
pubmed: 23390833
Oncol Rep. 2014 Jan;31(1):255-61
pubmed: 24253852
Tumour Biol. 2014 Oct;35(10):10237-48
pubmed: 25027407
Cancer Epidemiol Biomarkers Prev. 2016 Jan;25(1):16-27
pubmed: 26667886
World J Gastroenterol. 2016 Feb 7;22(5):1745-55
pubmed: 26855534
J Surg Oncol. 1989 Feb;40(2):112-8
pubmed: 2915539
Recent Pat Biotechnol. 2018;12(4):269-279
pubmed: 30062978
Immunol Today. 1993 Oct;14(10):506-12
pubmed: 7506035
Ann Surg. 1994 Feb;219(2):174-82
pubmed: 8129488
Dis Colon Rectum. 1994 Mar;37(3):272-7
pubmed: 8137675
Eur J Cancer. 1996 Jun;32A(7):1156-61
pubmed: 8758246
Dis Colon Rectum. 1997 Feb;40(2):145-9
pubmed: 9075747
Ann Surg. 1998 Jul;228(1):59-63
pubmed: 9671067
Br J Haematol. 1998 Dec;103(4):1129-37
pubmed: 9886331

Auteurs

Vera S Schellerer (VS)

Department of Surgery, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Krankenhausstr. 12, 91054, Erlangen, Germany. vera.schellerer@uk-erlangen.de.

Melanie C Langheinrich (MC)

Department of Surgery, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Krankenhausstr. 12, 91054, Erlangen, Germany.

Veronika Zver (V)

Department of Surgery, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Krankenhausstr. 12, 91054, Erlangen, Germany.

Robert Grützmann (R)

Department of Surgery, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Krankenhausstr. 12, 91054, Erlangen, Germany.

Michael Stürzl (M)

Division of Molecular and Experimental Surgery, Department of Surgery, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.

Olaf Gefeller (O)

Department of Medical Informatics, Biometry and Epidemiology, Friedrich-Alexander- University of Erlangen-Nürnberg, Erlangen, Germany.

Elisabeth Naschberger (E)

Division of Molecular and Experimental Surgery, Department of Surgery, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany.

Susanne Merkel (S)

Department of Surgery, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Krankenhausstr. 12, 91054, Erlangen, Germany.

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Classifications MeSH