Clinical and translational pharmacological aspects of the management of fibrous dysplasia of bone.


Journal

British journal of clinical pharmacology
ISSN: 1365-2125
Titre abrégé: Br J Clin Pharmacol
Pays: England
ID NLM: 7503323

Informations de publication

Date de publication:
06 2019
Historique:
received: 01 07 2018
revised: 08 11 2018
accepted: 10 11 2018
pubmed: 25 11 2018
medline: 14 4 2020
entrez: 25 11 2018
Statut: ppublish

Résumé

Fibrous dysplasia (FD) is a genetic, noninheritable rare bone disease caused by a postzygotic activating mutation of the α subunit of the stimulatory G-protein causing increased abnormal bone formation leading to pain, deformity and fractures. To date, no cure has been identified for FD/McCune-Albright syndrome (MAS) and treatment is symptomatic and aimed at decreasing pain and/or local bone turnover. Various drugs have been used to achieve clinical improvement in FD/MAS patients including bisphosphonates and denosumab, however further translational studies are also warranted to address unresolved pathophysiological issues and explore novel pharmacological targets for the management of FD/MAS. In this article, we review literature on the medical treatment of FD/MAS, discuss the unresolved pathophysiological issues and explore novel pharmacological targets for the management of FD/MAS.

Identifiants

pubmed: 30471134
doi: 10.1111/bcp.13820
pmc: PMC6533424
doi:

Substances chimiques

Bone Density Conservation Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1169-1179

Informations de copyright

© 2018 The Authors. British Journal of Clinical Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.

Références

Nucleic Acids Res. 2018 Jan 4;46(D1):D1091-D1106
pubmed: 29149325
J Clin Res Pediatr Endocrinol. 2011;3(1):40-2
pubmed: 21448334
J Clin Endocrinol Metab. 2014 Nov;99(11):4133-40
pubmed: 25033066
J Bone Miner Res. 2012 Jul;27(7):1462-70
pubmed: 22431375
J Clin Endocrinol Metab. 2003 Oct;88(10):4569-75
pubmed: 14557424
J Oral Maxillofac Surg. 2016 Oct;74(10):1983-99
pubmed: 27137436
Indian J Pediatr. 2012 May;79(5):667-9
pubmed: 21761121
Indian Pediatr. 2003 Sep;40(9):894-6
pubmed: 14530553
Pediatr Endocrinol Rev. 2007 Aug;4 Suppl 4:440-5
pubmed: 17982393
Case Rep Endocrinol. 2017;2017:7898713
pubmed: 28676838
Endocrinol Jpn. 1983 Oct;30(5):651-6
pubmed: 6423374
Clin Cancer Res. 2012 Aug 15;18(16):4415-24
pubmed: 22711702
J Oral Maxillofac Surg. 2012 Sep;70(9):e500-8
pubmed: 22907115
Rheumatology (Oxford). 2016 Oct;55(10):1735
pubmed: 27411478
Acta Paediatr. 2000 Feb;89(2):188-93
pubmed: 10709889
Joint Bone Spine. 2014 Dec;81(6):549-50
pubmed: 24962974
J Invest Dermatol. 1990 Jun;94(6 Suppl):2S-6S
pubmed: 2191052
Cancer Res. 2005 Oct 15;65(20):9426-35
pubmed: 16230406
J Biol Chem. 1996 May 3;271(18):10984-9
pubmed: 8631918
Clin Cases Miner Bone Metab. 2016 Sep-Dec;13(3):253-256
pubmed: 28228794
J Bone Miner Res. 2002 Apr;17(4):567-9
pubmed: 11924571
Orphanet J Rare Dis. 2018 May 2;13(1):72
pubmed: 29720212
J Bone Miner Res. 2004 Apr;19(4):571-7
pubmed: 15005844
Indian J Med Res. 2011 May;133:504-9
pubmed: 21623035
J Clin Invest. 1996 Jul 1;98(1):30-5
pubmed: 8690800
J Neurosurg. 2008 Nov;109(5):889-92
pubmed: 18976079
Case Rep Pediatr. 2016;2016:2329483
pubmed: 27747122
Indian Pediatr. 2010 Jul;47(7):633-5
pubmed: 20683120
Sarcoma. 2003;7(1):35-41
pubmed: 18521367
Curr Osteoporos Rep. 2016 Oct;14(5):178-86
pubmed: 27492469
J Bone Miner Res. 1997 Oct;12(10):1746-52
pubmed: 9333137
J Clin Densitom. 2001 Summer;4(2):167-72
pubmed: 11477309
Case Rep Endocrinol. 2015;2015:670809
pubmed: 26171261
J Med Case Rep. 2012 Jan 24;6:32
pubmed: 22273876
Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7693-6
pubmed: 10393882
J Clin Invest. 2003 Sep;112(5):683-92
pubmed: 12952917
J Bone Miner Res. 2015 Sep;30(9):1726-37
pubmed: 25736332
J Craniomaxillofac Surg. 2004 Feb;32(1):10-5
pubmed: 14729043
J Bone Miner Res. 2010 May;25(5):1103-16
pubmed: 19874199
Br J Clin Pharmacol. 2019 Jun;85(6):1169-1179
pubmed: 30471134
J Pediatr. 2000 Sep;137(3):403-9
pubmed: 10969268
J Bone Joint Surg Am. 1962 Mar;44-A:207-33
pubmed: 14036060
Osteoporos Int. 2014 Mar;25(3):1187-90
pubmed: 24158473
J Bone Miner Metab. 2002;20(3):170-3
pubmed: 11984700
J Bone Miner Res. 2016 May;31(5):929-39
pubmed: 26751835
Osteoporos Int. 2014 Feb;25(2):777-82
pubmed: 24311113
Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E418-E427
pubmed: 29158412
J Pediatr Orthop. 2002 Mar-Apr;22(2):255-60
pubmed: 11856942
J Clin Med Res. 2015 Nov;7(11):901-6
pubmed: 26491505
Indian J Endocrinol Metab. 2013 Jan;17(1):170-3
pubmed: 23776876
Bone. 2010 Feb;46(2):306-13
pubmed: 19766746
Oncol Lett. 2011 Nov;2(6):1239-1242
pubmed: 22848294
PLoS One. 2016 May 10;11(5):e0154680
pubmed: 27163152
Bone. 2003 Sep;33(3):434-42
pubmed: 13678786
Biomed Res Int. 2014;2014:670842
pubmed: 25530967
Joint Bone Spine. 2005 May;72(3):196-8
pubmed: 15850988
Calcif Tissue Int. 2002 Aug;71(2):121-8
pubmed: 12200645
Clin Endocrinol (Oxf). 2017 Nov;87(5):627-634
pubmed: 28699175
Eur Ann Otorhinolaryngol Head Neck Dis. 2017 Sep;134(4):229-235
pubmed: 28302454
N Engl J Med. 1991 Dec 12;325(24):1688-95
pubmed: 1944469
Pediatr Endocrinol Rev. 2007 Aug;4 Suppl 4:429-33
pubmed: 17982391
Proc Natl Acad Sci U S A. 1954 Oct;40(10):1014-8
pubmed: 16589582
Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E428-E437
pubmed: 29282319
J Bone Miner Res. 2006 Dec;21 Suppl 2:P114-9
pubmed: 17228999
Clin Rheumatol. 2008 Jun;27(6):809-12
pubmed: 18247080
Korean J Spine. 2015 Jun;12(2):95-8
pubmed: 26217391
Biomater Sci. 2016 Jul 21;4(7):1113-22
pubmed: 27180636
Case Rep Endocrinol. 2013;2013:589872
pubmed: 24369512
J Clin Endocrinol Metab. 1970 Sep;31(3):283-90
pubmed: 4916538
J Bone Miner Res. 2018 Nov;33(11):1990-1998
pubmed: 29924878
Curr Ther Res Clin Exp. 2009 Apr;70(2):161-72
pubmed: 24683227
J Bone Miner Res. 1997 Aug;12(8):1314-5
pubmed: 9258763
J Bone Miner Res. 2016 Dec;31(12):2167-2172
pubmed: 27340799
J Bone Miner Res. 1998 Jul;13(7):1084-91
pubmed: 9661072
Bone. 2004 Jul;35(1):235-42
pubmed: 15207763
Bone. 2003 Oct;33(4):582-8
pubmed: 14555262
Clin Endocrinol (Oxf). 2000 Nov;53(5):621-8
pubmed: 11106924
Rheumatology (Oxford). 2015 Sep;54(9):1747-9
pubmed: 26070936
Life Sci. 1999;65(11):1087-102
pubmed: 10503925
Nat Rev Cancer. 2002 Aug;2(8):584-93
pubmed: 12154351
Clin J Pain. 2006 Sep;22(7):587-600
pubmed: 16926574
Laryngoscope. 2013 Apr;123(4):823-8
pubmed: 23444264
J Craniofac Surg. 2017 May;28(3):706-708
pubmed: 28468152
J Clin Endocrinol Metab. 2014 Mar;99(3):891-7
pubmed: 24423331
J Pathol. 1999 Jan;187(2):249-58
pubmed: 10365102
Lancet. 1994 Apr 16;343(8903):953-4
pubmed: 7909013
Int J Pediatr Endocrinol. 2010;2010:432060
pubmed: 20976302
Calcif Tissue Int. 2014 Apr;94(4):384-95
pubmed: 24390518
Br J Pharmacol. 2017 Dec;174 Suppl 1:S225-S271
pubmed: 29055036
N Engl J Med. 2018 May 24;378(21):1987-1998
pubmed: 29791829
J Bone Miner Res. 2017 Feb;32(2):264-276
pubmed: 27649526
Orphanet J Rare Dis. 2012 May 24;7 Suppl 1:S3
pubmed: 22640953
J Bone Miner Res. 1998 Apr;13(4):581-9
pubmed: 9556058
Rheumatol Int. 2015 Apr;35(4):767-72
pubmed: 25230905

Auteurs

Marlous Rotman (M)

Department of Medicine, Division of Endocrinology & Centre for Bone Quality, Leiden University Medical Center, Leiden, the Netherlands.

Neveen Agnes Therese Hamdy (NAT)

Department of Medicine, Division of Endocrinology & Centre for Bone Quality, Leiden University Medical Center, Leiden, the Netherlands.

Natasha M Appelman-Dijkstra (NM)

Department of Medicine, Division of Endocrinology & Centre for Bone Quality, Leiden University Medical Center, Leiden, the Netherlands.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH