Financial gain- and loss-related BOLD signals in the human ventral tegmental area and substantia nigra pars compacta.
functional magnetic resonance imaging
midbrain
punishment
reward
salience
Journal
The European journal of neuroscience
ISSN: 1460-9568
Titre abrégé: Eur J Neurosci
Pays: France
ID NLM: 8918110
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
20
09
2018
revised:
09
11
2018
accepted:
19
11
2018
pubmed:
25
11
2018
medline:
15
7
2020
entrez:
25
11
2018
Statut:
ppublish
Résumé
Neurons in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNC) play central roles in reward-related behaviours. Nonhuman animal studies suggest that these neurons also process aversive events. However, our understanding of how the human VTA and SNC responds to such events is limited and has been hindered by the technical challenge of using functional magnetic resonance imaging (fMRI) to investigate a small structure where the signal is particularly vulnerable to physiological noise. Here we show, using methods optimized specifically for the midbrain (including high-resolution imaging, a novel registration protocol, and physiological noise modelling), a BOLD (blood-oxygen-level dependent) signal to both financial gain and loss in the VTA and SNC, along with a response to nil outcomes that are better or worse than expected in the VTA. Taken together, these findings suggest that the human VTA and SNC are involved in the processing of both appetitive and aversive financial outcomes in humans.
Identifiants
pubmed: 30471149
doi: 10.1111/ejn.14288
pmc: PMC6618000
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1196-1209Subventions
Organisme : Research Councils UK
Pays : International
Organisme : Medical Research Council
ID : U120085816
Pays : United Kingdom
Organisme : Medical Research Council
ID : U120064975
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_U120085816
Pays : United Kingdom
Organisme : The Royal Society
Pays : International
Informations de copyright
© 2018 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd.
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