Partial restoration of physiological UP-state activity by GABA pathway modulation in an acute brain slice model of epilepsy.
Journal
Neuropharmacology
ISSN: 1873-7064
Titre abrégé: Neuropharmacology
Pays: England
ID NLM: 0236217
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
31
08
2018
revised:
13
10
2018
accepted:
21
11
2018
pubmed:
26
11
2018
medline:
28
12
2019
entrez:
26
11
2018
Statut:
ppublish
Résumé
In addition to reducing seizures, anti-epileptic treatments should preserve physiological network activity. Here, we used a thalamocortical slice preparation displaying physiological slow oscillations to investigate the effects of anticonvulsant drugs on physiological activity and epileptiform activity in two pharmacological epilepsy models. Thus, we compared the effects of GABA pharmacology on spontaneous physiological and pathological events in slices of the mouse barrel cortex. We show that both reducing inhibition using GABA
Identifiants
pubmed: 30472273
pii: S0028-3908(18)30602-6
doi: 10.1016/j.neuropharm.2018.11.032
pii:
doi:
Substances chimiques
Anticonvulsants
0
GABA Modulators
0
Pyridazines
0
gabazine
99460MG420
Magnesium
I38ZP9992A
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
394-405Informations de copyright
Copyright © 2018. Published by Elsevier Ltd.