Neutrophils mitigate the systemic host response during endotoxemia in mice.
Animals
Biomarkers
/ blood
Cell Wall
/ immunology
Chemokines
/ immunology
Cytokines
/ immunology
Endothelium, Vascular
/ immunology
Endotoxemia
/ blood
Female
Gram-Negative Bacteria
/ immunology
Host Microbial Interactions
/ immunology
Lipopolysaccharides
/ immunology
Mice
Mice, Inbred C57BL
Neutrophils
/ immunology
chemokines
cytokines
inflammation
neutrophil
Journal
Immunology
ISSN: 1365-2567
Titre abrégé: Immunology
Pays: England
ID NLM: 0374672
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
26
03
2018
revised:
01
11
2018
accepted:
07
11
2018
pubmed:
26
11
2018
medline:
30
8
2019
entrez:
26
11
2018
Statut:
ppublish
Résumé
Recent studies have suggested that neutrophils can exert anti-inflammatory effects. To determine the role of neutrophils in the acute response to lipopolysaccharide (LPS), a component of the Gram-negative bacterial cell wall, we challenged neutrophil-depleted and control mice with LPS and analyzed the plasma concentrations of biomarkers indicative of the cytokine and chemokine network, activation of coagulation and the vascular endothelium, and cellular injury. We here show that neutrophils serve an anti-inflammatory role upon LPS administration, as reflected by sustained elevations of multiple cytokines and chemokines, and enhanced release of nucleosomes in mice depleted of neutrophils, compared with control mice.
Identifiants
pubmed: 30472736
doi: 10.1111/imm.13026
pmc: PMC6376271
doi:
Substances chimiques
Biomarkers
0
Chemokines
0
Cytokines
0
Lipopolysaccharides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
277-281Informations de copyright
© 2018 The Authors. Immunology Published by John Wiley & Sons Ltd.
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