Lactate: A Metabolic Driver in the Tumour Landscape.

Animals Humans Lactic Acid / metabolism Neoplasms / metabolism
mitochondria tumour metabolism tumour microenvironment tumour–stroma interplay

Journal

Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674

Informations de publication

Date de publication:
02 2019
Historique:
received: 02 08 2018
revised: 14 09 2018
accepted: 25 10 2018
pubmed: 27 11 2018
medline: 13 4 2019
entrez: 27 11 2018
Statut: ppublish

Résumé

The presence of lactate in human tumours has been long neglected, confined to the role of a waste product derived from glycolysis and as a biomarker of malignancy. More recently, lactate has been rediscovered as signalling molecule that plays important roles in the regulation of the metabolic pathways, the immune response, and cell-to-cell communication within the tumour microenvironment. This review examines recent discoveries about the functional role of lactate in shaping the behaviour and the phenotype of tumour and tumour-associated cells, and describes potential clinical approaches to target lactate transport and metabolism in tumours.

Identifiants

DOI: 10.1016/j.tibs.2018.10.011 PMID: 30473428
pubmed: 30473428
pii: S0968-0004(18)30227-5
doi: 10.1016/j.tibs.2018.10.011
pii:
doi:

Substances chimiques

Lactic Acid 33X04XA5AT

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

153-166

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

Auteurs

Luigi Ippolito (L)

Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy.

Andrea Morandi (A)

Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy.

Elisa Giannoni (E)

Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy.

Paola Chiarugi (P)

Department of Experimental and Clinical Biomedical Sciences, University of Florence, 50134 Florence, Italy. Electronic address: paola.chiarugi@unifi.it.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Lactate: A Metabolic Driver in the Tumour Landscape.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Lactate: A Metabolic Driver in the Tumour Landscape.
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Lactates › Acide lactique › Lactate: A Metabolic Driver in the Tumour Landscape.
questionsmedicales.fr › Tumeurs › Lactate: A Metabolic Driver in the Tumour Landscape.