Maternal Hypertensive Disorders of Pregnancy and Offspring Risk of Hypertension: A Population-Based Cohort and Sibling Study.
Adult
Blood Pressure
/ physiology
Female
Follow-Up Studies
Humans
Hypertension
/ epidemiology
Incidence
Infant, Newborn
Male
Population Surveillance
/ methods
Pregnancy
Pregnancy Complications, Cardiovascular
Prenatal Exposure Delayed Effects
/ epidemiology
Retrospective Studies
Risk Assessment
/ methods
Risk Factors
Siblings
Sweden
/ epidemiology
blood pressure
cardiovascular diseases
epidemiologic studies
hypertension
pre-eclampsia
pregnancy
preventive medicine
“Hypertension, Pregnancy-Induced”
Journal
American journal of hypertension
ISSN: 1941-7225
Titre abrégé: Am J Hypertens
Pays: United States
ID NLM: 8803676
Informations de publication
Date de publication:
16 03 2019
16 03 2019
Historique:
received:
25
03
2018
revised:
09
07
2018
accepted:
20
11
2018
pubmed:
27
11
2018
medline:
7
7
2020
entrez:
27
11
2018
Statut:
ppublish
Résumé
Women with a history of hypertensive disorders of pregnancy (HDP) are at increased risk of hypertension, cardiovascular disease, and type 2 diabetes. Offspring from pregnancies complicated by HDP also have worse cardiometabolic status in childhood and young adulthood, but the offspring risk of clinical hypertension in adulthood is largely unknown. We studied 13,893 first-born adult offspring (49.4% female) who attended a structured population-based primary care visit (The Västerbotten Health Survey) at age 40 years in Sweden between 1994 and 2013. Data on maternal HDP were collected from a population-based birth register. We investigated the association between maternal HDP and the risk of adult offspring hypertension and worse cardiometabolic risk factor status utilizing multivariable poisson and linear regression models. We also conducted a sibling comparison, which inherently accounted for familial factors shared by siblings (N = 135). Offspring participants of women with HDP (N = 383, 2.8%) had increased relative risk of hypertension (1.67, 95% confidence interval: 1.38, 2.01) and also higher mean body mass index, systolic blood pressure, diastolic blood pressure, and worse 2-hour 75 g oral glucose tolerance test result at age 40 years. No difference was observed for serum cholesterol. Point estimates for the cardiometabolic risk factors were attenuated in the sibling analyses. Offspring born to mothers with a history of HDP are on an adverse cardiometabolic trajectory and should be considered as concomitant targets for primordial prevention of hypertension in the maternal post-pregnancy period.
Sections du résumé
BACKGROUND
Women with a history of hypertensive disorders of pregnancy (HDP) are at increased risk of hypertension, cardiovascular disease, and type 2 diabetes. Offspring from pregnancies complicated by HDP also have worse cardiometabolic status in childhood and young adulthood, but the offspring risk of clinical hypertension in adulthood is largely unknown.
METHODS
We studied 13,893 first-born adult offspring (49.4% female) who attended a structured population-based primary care visit (The Västerbotten Health Survey) at age 40 years in Sweden between 1994 and 2013. Data on maternal HDP were collected from a population-based birth register. We investigated the association between maternal HDP and the risk of adult offspring hypertension and worse cardiometabolic risk factor status utilizing multivariable poisson and linear regression models. We also conducted a sibling comparison, which inherently accounted for familial factors shared by siblings (N = 135).
RESULTS
Offspring participants of women with HDP (N = 383, 2.8%) had increased relative risk of hypertension (1.67, 95% confidence interval: 1.38, 2.01) and also higher mean body mass index, systolic blood pressure, diastolic blood pressure, and worse 2-hour 75 g oral glucose tolerance test result at age 40 years. No difference was observed for serum cholesterol. Point estimates for the cardiometabolic risk factors were attenuated in the sibling analyses.
CONCLUSION
Offspring born to mothers with a history of HDP are on an adverse cardiometabolic trajectory and should be considered as concomitant targets for primordial prevention of hypertension in the maternal post-pregnancy period.
Identifiants
pubmed: 30475953
pii: 5205123
doi: 10.1093/ajh/hpy176
pmc: PMC6420682
doi:
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
331-334Subventions
Organisme : Medical Research Council
ID : MC_UU_12013/5
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M009351/1
Pays : United Kingdom
Informations de copyright
© The Author(s) 2018. Published by Oxford University Press on behalf of American Journal of Hypertension, Ltd.
Références
Am J Obstet Gynecol. 2017 Mar;216(3):281.e1-281.e7
pubmed: 27823919
J Epidemiol Community Health. 2016 Apr;70(4):414-22
pubmed: 26347276
Eur Heart J. 2012 Feb;33(3):335-45
pubmed: 21862461
Glob Health Action. 2012;5:
pubmed: 22855645
BMJ. 2017 Jul 12;358:j3024
pubmed: 28701338
Clin Sci (Lond). 2012 Jul;123(2):53-72
pubmed: 22455350
Eur J Epidemiol. 2018 Oct;33(10):1003-1010
pubmed: 30062549
Scand J Public Health Suppl. 2003;61:18-24
pubmed: 14660243
Stroke. 2009 Apr;40(4):1176-80
pubmed: 19265049
Stat Med. 2005 Oct 15;24(19):2911-35
pubmed: 16152135
Hypertension. 2017 Apr;69(4):591-598
pubmed: 28223467
BMJ Open. 2011 May 24;1(1):e000101
pubmed: 22021762
Pediatrics. 2012 Jun;129(6):e1552-61
pubmed: 22614768
Glob Health Action. 2010 Mar 22;3:
pubmed: 20339479
BMC Genet. 2007 Sep 10;8:60
pubmed: 17845730
Epidemiology. 1999 Sep;10(5):518-22
pubmed: 10468424