Cefazolin vs. anti-staphylococcal penicillins for treatment of methicillin-susceptible Staphylococcus aureus bloodstream infections in acutely ill adult patients: Results of a systematic review and meta-analysis.
Anti-staphylococcal penicillin
Antibiotic stewardship
Bloodstream infection
Cefazolin
Methicillin-susceptible Staphylococcus aureus
Journal
International journal of antimicrobial agents
ISSN: 1872-7913
Titre abrégé: Int J Antimicrob Agents
Pays: Netherlands
ID NLM: 9111860
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
13
06
2018
revised:
06
11
2018
accepted:
17
11
2018
pubmed:
27
11
2018
medline:
8
6
2019
entrez:
27
11
2018
Statut:
ppublish
Résumé
A systematic literature review and meta-analysis was conducted to evaluate the comparative efficacy and tolerability of cefazolin vs. anti-staphylococcal penicillins (ASPs) for methicillin-susceptible Staphylococcus aureus (MSSA) bloodstream infections (BSI). Utilizing published regression models, included studies were stratified into subgroups of high and low pre-probability of mortality. Cefazolin was associated with significantly lower rates of treatment failure (odds ratio [OR]: 0.70; 95% confidence interval [CI]: 0.61-0.82; P<0.001; I
Identifiants
pubmed: 30476572
pii: S0924-8579(18)30338-8
doi: 10.1016/j.ijantimicag.2018.11.013
pii:
doi:
Substances chimiques
Anti-Bacterial Agents
0
Penicillins
0
Cefazolin
IHS69L0Y4T
Types de publication
Comparative Study
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
225-233Informations de copyright
Copyright © 2018 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.