MTHFR AND ApoE genetic variants association with sudden sensorineural hearing loss.
Adult
Apolipoproteins E
/ genetics
Case-Control Studies
Female
Gene Frequency
Genetic Association Studies
Genetic Variation
/ genetics
Genotype
Genotyping Techniques
/ methods
Hearing Loss, Sensorineural
/ genetics
Hearing Loss, Sudden
/ genetics
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2)
/ genetics
Middle Aged
Polymerase Chain Reaction
Polymorphism, Restriction Fragment Length
Apolipoprotein E
Genetic variation
Methylenetetrahydrofolate reductase
Sudden sensorineural hearing loss
Journal
American journal of otolaryngology
ISSN: 1532-818X
Titre abrégé: Am J Otolaryngol
Pays: United States
ID NLM: 8000029
Informations de publication
Date de publication:
Historique:
received:
03
10
2018
accepted:
28
10
2018
pubmed:
28
11
2018
medline:
22
6
2019
entrez:
28
11
2018
Statut:
ppublish
Résumé
Although the pathogenesis of sudden sensorineural hearing loss (SSNHL) is not clear, however several causes including genetic factors seems to be implicated. We hypothesized that common genetic variants might be involved in SSNHL. SSNHL is known to be an idiopathic disease because the causative factors have not been identified. Several causes including genetic and viral infection besides immune system reaction, neurological disorders, medications, etc. have been previously reported. We examined the association between ApoE and MTHFR gene variants in SSNHL. This study includes case-control scheme encompassing a total of 177 individuals, include patients inflicted with SSNHL and healthy subjects as control group. Genotyping of MTHFR and ApoE variants was conducted by PCR - RFLP method. Our study showed that MTHFR rs1801133 allele frequency is significantly different between cases and controls. Also genotype distribution of ApoE was significantly different between patients and healthy controls. MTHFR C677T and ApoE gene variant may be associated with sudden sensorineural hearing loss in an Iranian population.
Sections du résumé
HYPOTHESIS
OBJECTIVE
Although the pathogenesis of sudden sensorineural hearing loss (SSNHL) is not clear, however several causes including genetic factors seems to be implicated. We hypothesized that common genetic variants might be involved in SSNHL.
BACKGROUND
BACKGROUND
SSNHL is known to be an idiopathic disease because the causative factors have not been identified. Several causes including genetic and viral infection besides immune system reaction, neurological disorders, medications, etc. have been previously reported. We examined the association between ApoE and MTHFR gene variants in SSNHL.
METHODS
METHODS
This study includes case-control scheme encompassing a total of 177 individuals, include patients inflicted with SSNHL and healthy subjects as control group. Genotyping of MTHFR and ApoE variants was conducted by PCR - RFLP method.
RESULT
RESULTS
Our study showed that MTHFR rs1801133 allele frequency is significantly different between cases and controls. Also genotype distribution of ApoE was significantly different between patients and healthy controls.
CONCLUSIONS
CONCLUSIONS
MTHFR C677T and ApoE gene variant may be associated with sudden sensorineural hearing loss in an Iranian population.
Identifiants
pubmed: 30477909
pii: S0196-0709(18)30926-8
doi: 10.1016/j.amjoto.2018.10.015
pii:
doi:
Substances chimiques
Apolipoproteins E
0
MTHFR protein, human
EC 1.5.1.20
Methylenetetrahydrofolate Reductase (NADPH2)
EC 1.5.1.20
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
260-264Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.