Monitoring treatment response to tafamidis by serial native T1 and extracellular volume in transthyretin amyloid cardiomyopathy.
Amyloidosis
Cardiac magnetic resonance
Extracellular volume
Native T1
Tafamidis
Transthyretin
Journal
ESC heart failure
ISSN: 2055-5822
Titre abrégé: ESC Heart Fail
Pays: England
ID NLM: 101669191
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
09
08
2018
accepted:
13
10
2018
pubmed:
28
11
2018
medline:
16
3
2019
entrez:
28
11
2018
Statut:
ppublish
Résumé
Tafamidis meglumine, a transthyretin (TTR) stabilizer, is effective in delaying the progression of neuropathy in TTR amyloidosis with Val30Met mutations. However, its efficacy in TTR amyloid cardiomyopathy is not fully elucidated. Herein, we report a 73-year-old Japanese man with a diagnosis of TTR amyloid cardiomyopathy with Val30Met mutation treated with tafamidis. To evaluate treatment response, cardiac magnetic resonance imaging was performed before and after 12 months of tafamidis treatment. Native T1, extracellular volume, and left ventricular mass showed no obvious worsening, and findings of other diagnostic studies also supported the efficacy of tafamidis to delay the progression of amyloid cardiomyopathy. Our case suggests that serial native T1 and extracellular volume may be novel non-invasive imaging methods to monitor the treatment response to TTR stabilizers in cardiac amyloidosis and also that tafamidis may be effective in suppressing cardiac progression in TTR amyloid cardiomyopathy with Val30Met mutation.
Identifiants
pubmed: 30478886
doi: 10.1002/ehf2.12382
pmc: PMC6352892
doi:
Substances chimiques
Benzoxazoles
0
tafamidis
8FG9H9D31J
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
232-236Informations de copyright
© 2018 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.
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