Synthesis, anticancer activity and cytotoxicity of 7-O-β-d-galactosyl-polyethylene glycol-epothilone B.
7-O-β-d-galactosyl-PEG-epothilone B
anticancer activity
synthesis
toxicity
Journal
Chemical biology & drug design
ISSN: 1747-0285
Titre abrégé: Chem Biol Drug Des
Pays: England
ID NLM: 101262549
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
25
08
2018
revised:
25
10
2018
accepted:
11
11
2018
pubmed:
28
11
2018
medline:
16
1
2020
entrez:
28
11
2018
Statut:
ppublish
Résumé
Epothilone, the macrolide compound produced by Sorangium cellulosum, has antitumor activity. Its anti-tumor mechanism is similar to that of paclitaxel, which promotes the polymerization of tubulin and induces apoptosis. Herein, 7-O-β-d-galactosyl-polyethylene glycol-epothilone B 6 was synthesized. It showed that the toxicity of the synthesized compound was 1/182 of the epothilone B. In addition, compound 6 also had significant anticancer activity under the action of enzyme.
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Epothilones
0
Polyethylene Glycols
3WJQ0SDW1A
epothilone B
UEC0H0URSE
Galactose
X2RN3Q8DNE
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
539-543Informations de copyright
© 2018 John Wiley & Sons A/S.