Vitamin D controls the capacity of human dendritic cells to induce functional regulatory T cells by regulation of glucose metabolism.

Autoimmunity Calcitriol / immunology Cells, Cultured Dendritic Cells / immunology Glucose / immunology Humans Metabolomics Phosphofructokinase-2 / immunology T-Lymphocytes, Regulatory / immunology
1α,25(OH)(2)D(3) Dendritic cells Immunometabolism PFKFB4 Regulatory T cells Tolerogenicity

Journal

The Journal of steroid biochemistry and molecular biology
ISSN: 1879-1220
Titre abrégé: J Steroid Biochem Mol Biol
Pays: England
ID NLM: 9015483

Informations de publication

Date de publication:
03 2019
Historique:
received: 01 10 2018
revised: 21 11 2018
accepted: 23 11 2018
pubmed: 28 11 2018
medline: 22 5 2019
entrez: 28 11 2018
Statut: ppublish

Résumé

Tolerogenic dendritic cells (tolDCs) instruct regulatory T cells (Tregs) to dampen autoimmunity. Active vitamin D

Identifiants

DOI: 10.1016/j.jsbmb.2018.11.011 PMID: 30481575
pubmed: 30481575
pii: S0960-0760(18)30606-X
doi: 10.1016/j.jsbmb.2018.11.011
pii:
doi:

Substances chimiques

PFKFB4 protein, human 0
Phosphofructokinase-2 EC 2.7.1.105
Calcitriol FXC9231JVH
Glucose IY9XDZ35W2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

134-145

Informations de copyright

Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

An-Sofie Vanherwegen (AS)

Clinical and Experimental Endocrinology, KU, Leuven, Belgium.

Guy Eelen (G)

Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Leuven, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium.

Gabriela Bomfim Ferreira (GB)

Clinical and Experimental Endocrinology, KU, Leuven, Belgium.

Bart Ghesquière (B)

Metabolomics Core Facility, Center for Cancer Biology, VIB, Leuven,Belgium; Metabolomics Core Facility, Department of Oncology, KU Leuven, Leuven, Belgium.

Dana Paulina Cook (DP)

Clinical and Experimental Endocrinology, KU, Leuven, Belgium.

Tanja Nikolic (T)

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.

Bart Roep (B)

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands; Department of Diabetes Immunology, Diabetes & Metabolism Research Institute, Beckman Research Institute, City of Hope, Duarte, CA, USA.

Peter Carmeliet (P)

Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Leuven, Belgium; Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium.

Sucheta Telang (S)

Division of Hematology/Oncology, Department of Medicine, J. Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.

Chantal Mathieu (C)

Clinical and Experimental Endocrinology, KU, Leuven, Belgium.

Conny Gysemans (C)

Clinical and Experimental Endocrinology, KU, Leuven, Belgium. Electronic address: conny.gysemans@kuleuven.be.

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Classifications MeSH

questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Auto-immunité › Vitamin D controls the capacity of human...
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholécalciférol › Hydroxycholécalciférols › Dihydroxycholécalciférols › Calcitriol › Vitamin D controls the capacity of human...
questionsmedicales.fr › Cellules › Cellules cultivées › Vitamin D controls the capacity of human...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › Vitamin D controls the capacity of human...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Vitamin D controls the capacity of human...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Vitamin D controls the capacity of human...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Métabolomique › Vitamin D controls the capacity of human...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Fructokinases › Phosphofructokinases › Phosphofructokinase-2 › Vitamin D controls the capacity of human...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Vitamin D controls the capacity of human...