Anaphylactic shock after sugammadex administration, induced by formation of a sugammadex-rocuronium complex -a case report.
Anaphylactic shock
Cyclodextrin
Epinephrine
Hypersensitivity
Rocuronium
Sugammadex
Journal
Korean journal of anesthesiology
ISSN: 2005-7563
Titre abrégé: Korean J Anesthesiol
Pays: Korea (South)
ID NLM: 101502451
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
11
08
2018
accepted:
26
11
2018
pubmed:
28
11
2018
medline:
13
8
2020
entrez:
28
11
2018
Statut:
ppublish
Résumé
Sugammadex is a reversal agent for non-depolarizing neuromuscular blockers and widely used worldwide on account of its rapid and effective reversal from neuromuscular blockade, despite its advantages, multiple cases of sugammadex-induced anaphylactic shock have been reported. A 42-year-old man developed anaphylactic shock in the postanesthesia care unit. Initially, sugammadex was suspected as the causative agent, but an intradermal skin test revealed negative results. A further skin test was performed with sugammadex-rocuronium complex that yielded positive results. Anesthesiologists and healthcare providers should be aware of the possibility of anaphylaxis from the sugammadex-rocuronium complex, as well as from sugammadex or rocuronium alone.
Sections du résumé
BACKGROUND
Sugammadex is a reversal agent for non-depolarizing neuromuscular blockers and widely used worldwide on account of its rapid and effective reversal from neuromuscular blockade, despite its advantages, multiple cases of sugammadex-induced anaphylactic shock have been reported.
CASE
A 42-year-old man developed anaphylactic shock in the postanesthesia care unit. Initially, sugammadex was suspected as the causative agent, but an intradermal skin test revealed negative results. A further skin test was performed with sugammadex-rocuronium complex that yielded positive results.
CONCLUSIONS
Anesthesiologists and healthcare providers should be aware of the possibility of anaphylaxis from the sugammadex-rocuronium complex, as well as from sugammadex or rocuronium alone.
Identifiants
pubmed: 30481948
pii: kja.d.18.00232
doi: 10.4097/kja.d.18.00232
pmc: PMC6781209
doi:
Substances chimiques
Neuromuscular Nondepolarizing Agents
0
Sugammadex
361LPM2T56
Rocuronium
WRE554RFEZ
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
495-499Commentaires et corrections
Type : CommentIn
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