Auxiliary partial orthotopic liver transplantation for acute liver failure.


Journal

Annals of the Royal College of Surgeons of England
ISSN: 1478-7083
Titre abrégé: Ann R Coll Surg Engl
Pays: England
ID NLM: 7506860

Informations de publication

Date de publication:
Mar 2019
Historique:
pubmed: 30 11 2018
medline: 20 3 2019
entrez: 29 11 2018
Statut: ppublish

Résumé

Auxiliary partial orthotopic liver transplantation (APOLT) in acute liver failure acts as a bridge to native liver regeneration with potential for immunosuppression free survival. While technical concerns limit its universal acceptance, the indications in acute liver failure also need to be examined for this procedure to ultimately succeed. We present the case of an eight-month-old girl with cryptogenic acute liver failure who underwent APOLT. She developed postoperative liver dysfunction, most likely owing to the persistence of the diseased native liver, ultimately leading to an orthotopic retransplantation. She remains well on follow-up review. A tempered approach to selecting patients for APOLT (especially with regard to aetiology of acute liver failure) makes it a safe and effective alternative to orthotopic liver transplantation.

Identifiants

pubmed: 30482030
doi: 10.1308/rcsann.2018.0204
pmc: PMC6400919
doi:

Substances chimiques

Aspartate Aminotransferases EC 2.6.1.1
Bilirubin RFM9X3LJ49

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e71-e72

Références

J Hepatol. 1999 Apr;30(4):699-705
pubmed: 10207813
Ann Surg. 2001 Dec;234(6):723-31
pubmed: 11729378
Liver Transpl. 2008 Oct;14(10):1437-48
pubmed: 18825705
Ann Surg. 2010 Feb;251(2):351-6
pubmed: 20054274
J Hepatol. 2012 Aug;57(2):288-96
pubmed: 22521347
Liver Transpl. 2016 Sep;22(9):1265-74
pubmed: 27357489

Auteurs

M Shrivastav (M)

Institute of Liver Disease & Transplantation, Gleneagles Global Health City , Chennai , India.
Institute of Liver Disease & Transplantation, Dr.Rela Institute & Medical Centre, Bharat Institute of Higher Education & Research , Chennai , India.

A Rammohan (A)

Institute of Liver Disease & Transplantation, Gleneagles Global Health City , Chennai , India.
Institute of Liver Disease & Transplantation, Dr.Rela Institute & Medical Centre, Bharat Institute of Higher Education & Research , Chennai , India.

M S Reddy (MS)

Institute of Liver Disease & Transplantation, Gleneagles Global Health City , Chennai , India.
Institute of Liver Disease & Transplantation, Dr.Rela Institute & Medical Centre, Bharat Institute of Higher Education & Research , Chennai , India.

M Rela (M)

Institute of Liver Disease & Transplantation, Gleneagles Global Health City , Chennai , India.
Institute of Liver Disease & Transplantation, Dr.Rela Institute & Medical Centre, Bharat Institute of Higher Education & Research , Chennai , India.
Institute of Liver Studies, King's College Hospital , London , UK.

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