Severe conduct problems in adolescence and risk of schizophrenia in early adulthood.


Journal

Early intervention in psychiatry
ISSN: 1751-7893
Titre abrégé: Early Interv Psychiatry
Pays: Australia
ID NLM: 101320027

Informations de publication

Date de publication:
12 2019
Historique:
received: 03 01 2018
revised: 12 09 2018
accepted: 04 11 2018
pubmed: 30 11 2018
medline: 18 2 2020
entrez: 29 11 2018
Statut: ppublish

Résumé

Reform school (RS) is a foster care institution for adolescents with severe conduct problems. Both instability of early rearing environment and severe conduct problems in adolescence may associate with later psychotic disorders. We studied whether the risk of schizophrenia in adulthood is elevated in RS adolescents, and whether it is related to the age at first foster care placement or placement instability. Adult age schizophrenia spectrum disorder data from RS subjects (N = 1099) were compared to a comparison group matched by age, sex, and place of birth (N = 5437) in a register based follow-up study, with up to 23 years follow-up time. Schizophrenia was also predicted with chosen placement factors. Cox proportional regression model was used in the analysis. RS subjects had an 8-fold (HR = 7.82, 95% CI 5.63-10.87) risk of schizophrenia compared to the comparison group. RS subjects also had an earlier age of schizophrenia onset. RS cohort, gender, placement instability, or age during the first out-of-home placement did not predict later schizophrenia. Adolescents with severe conduct problems are a specific high-risk group for later schizophrenia. The risk manifests early, which compromises the pathway to the adult well-being. Specialized screening procedures for psychosis risk should be implemented in the standard clinical procedures when working with adolescents with severe behaviour problems, and early intervention programs should be available.

Identifiants

pubmed: 30485663
doi: 10.1111/eip.12767
doi:

Types de publication

Comparative Study Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1338-1344

Subventions

Organisme : Päivikki ja Sakari Sohlbergin Säätiö
Pays : International
Organisme : Yrjö Jahnssonin Säätiö
ID : 6783
Pays : International

Informations de copyright

© 2018 John Wiley & Sons Australia, Ltd.

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Auteurs

Marko Manninen (M)

National Institute for Health and Welfare, Mental Health Unit, Helsinki, Finland.

Reetta Latvala (R)

Department of Psychology, University of Helsinki, Helsinki, Finland.

Minna Torniainen-Holm (M)

National Institute for Health and Welfare, Mental Health Unit, Helsinki, Finland.

Jaana Suvisaari (J)

National Institute for Health and Welfare, Mental Health Unit, Helsinki, Finland.

Maija Lindgren (M)

National Institute for Health and Welfare, Mental Health Unit, Helsinki, Finland.

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