Whole-Blood DNA Methylation Markers in Early Detection of Breast Cancer: A Systematic Literature Review.
Journal
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
ISSN: 1538-7755
Titre abrégé: Cancer Epidemiol Biomarkers Prev
Pays: United States
ID NLM: 9200608
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
06
04
2018
revised:
09
07
2018
accepted:
20
11
2018
pubmed:
30
11
2018
medline:
2
5
2020
entrez:
30
11
2018
Statut:
ppublish
Résumé
Whole-blood DNA methylation markers have been suggested as potential biomarkers for early detection of breast cancer. We conducted a systematic review of the literature on whole-blood DNA methylation markers for breast cancer detection. PubMed and ISI Web of Knowledge were searched up to May 29, 2018. Overall, 33 studies evaluating 355 markers were included. The diagnostic value of most individual markers was relatively modest, with only six markers showing sensitivity >40% at specificity >75% [only 2 (
Identifiants
pubmed: 30487132
pii: 1055-9965.EPI-18-0378
doi: 10.1158/1055-9965.EPI-18-0378
doi:
Substances chimiques
Biomarkers, Tumor
0
Genetic Markers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
496-505Informations de copyright
©2018 American Association for Cancer Research.