Lipid acquisition and tissue storage in hagfish: new insights from an ancient vertebrate.
Agnathan
Dietary lipids
Fatty acid
Insulin
Lipid droplets
Transport
Journal
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology
ISSN: 1432-136X
Titre abrégé: J Comp Physiol B
Pays: Germany
ID NLM: 8413200
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
15
10
2018
accepted:
22
11
2018
revised:
15
11
2018
pubmed:
30
11
2018
medline:
28
3
2020
entrez:
30
11
2018
Statut:
ppublish
Résumé
Hagfishes are ancient vertebrates, which have the ability to tolerate nearly a year of food deprivation with energy during fasting maintained using lipid stores. While lipid transporters are evolutionarily conserved, there are relatively few studies examining mechanisms of lipid acquisition in teleosts and no reports in the primitive and evolutionarily important agnathans. We examined tissue lipid droplet distribution and used gut sac preparations to characterize uptake mechanisms of the monounsaturated fatty acid, oleic acid (OA; 18:1 cis-9), in the Pacific hagfish. OA absorption was carrier-mediated and demonstrated saturable concentration-dependent uptake with an affinity constant of 55 ± 7 µM, and a maximal rate of uptake of 1311 ± 97 pmol cm
Identifiants
pubmed: 30488102
doi: 10.1007/s00360-018-1196-8
pii: 10.1007/s00360-018-1196-8
doi:
Substances chimiques
Blood Glucose
0
Insulin
0
Oleic Acid
2UMI9U37CP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
37-45Références
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