Drug-Controlled Release Based on Complementary Base Pairing Rules for Photodynamic-Photothermal Synergistic Tumor Treatment.
Adenine
/ chemistry
Animals
Base Pairing
/ physiology
Cell Line, Tumor
Combined Modality Therapy
DNA, Complementary
/ chemistry
Delayed-Action Preparations
/ administration & dosage
Drug Delivery Systems
/ methods
Drug Liberation
/ genetics
Drug Synergism
Female
Humans
Hyperthermia, Induced
/ methods
Indoles
/ chemistry
Isoindoles
Mice
Mice, Inbred BALB C
Mice, Nude
Nanoparticles
/ chemistry
Neoplasms
/ therapy
Organometallic Compounds
/ chemistry
Photochemotherapy
/ methods
Photosensitizing Agents
/ administration & dosage
Phototherapy
/ methods
Polymers
/ chemistry
Xenograft Model Antitumor Assays
Zinc Compounds
complementary base pairing rules
drug delivery
photodynamic-photothermal therapy
photothermal controlled drug release
polydopamine
Journal
Small (Weinheim an der Bergstrasse, Germany)
ISSN: 1613-6829
Titre abrégé: Small
Pays: Germany
ID NLM: 101235338
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
22
09
2018
revised:
05
11
2018
pubmed:
30
11
2018
medline:
26
6
2020
entrez:
30
11
2018
Statut:
ppublish
Résumé
Controlled drug release systems can enhance the safety and availability but avoid the side effect of drugs. Herein, the concept of DNA complementary base pairing rules in biology is used to design and prepare a photothermal-triggered drug release system. Adenine (A) modified polydopamine nanoparticles (A-PDA, photothermal reagent) can effectively bind with thymine (T) modified Zinc phthalocyanine (T-ZnPc, photosensitizer) forming A-PDA = T-ZnPc (PATP) complex based on A = T complementary base pairing rules. Similar to DNA, whose base pairing in double strands will break by heating, T-ZnPc can be effectively released from A-PDA after near infrared irradiation-triggered light-thermal conversion to obtain satisfactory photodynamic-photothermal synergistic tumor treatment. In addition, PDA can carry abundant Gd
Identifiants
pubmed: 30488638
doi: 10.1002/smll.201803926
doi:
Substances chimiques
DNA, Complementary
0
Delayed-Action Preparations
0
Indoles
0
Isoindoles
0
Organometallic Compounds
0
Photosensitizing Agents
0
Polymers
0
Zinc Compounds
0
polydopamine
0
Zn(II)-phthalocyanine
14320-04-8
zinc(II) phthalocyanine trisulfonic acid
61569-02-6
Adenine
JAC85A2161
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1803926Informations de copyright
© 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.