Risk-Reducing Oophorectomy and Breast Cancer Risk Across the Spectrum of Familial Risk.
Journal
Journal of the National Cancer Institute
ISSN: 1460-2105
Titre abrégé: J Natl Cancer Inst
Pays: United States
ID NLM: 7503089
Informations de publication
Date de publication:
01 03 2019
01 03 2019
Historique:
received:
10
04
2018
revised:
02
08
2018
accepted:
07
09
2018
pubmed:
30
11
2018
medline:
12
3
2020
entrez:
30
11
2018
Statut:
ppublish
Résumé
There remains debate about whether risk-reducing salpingo-oophorectomy (RRSO), which reduces ovarian cancer risk, also reduces breast cancer risk. We examined the association between RRSO and breast cancer risk using a prospective cohort of 17 917 women unaffected with breast cancer at baseline (7.2% known carriers of BRCA1 or BRCA2 mutations). During a median follow-up of 10.7 years, 1046 women were diagnosed with incident breast cancer. Modeling RRSO as a time-varying exposure, there was no association with breast cancer risk overall (hazard ratio [HR] = 1.04, 95% confidence interval [CI] = 0.87 to 1.24) or by tertiles of predicted absolute risk based on family history (HR = 0.68, 95% CI = 0.32 to 1.47, HR = 0.94, 95% CI = 0.70 to 1.26, and HR = 1.10, 95% CI = 0.88 to 1.39, for lowest, middle, and highest tertile of risk, respectively) or for BRCA1 and BRCA2 mutation carriers when examined separately. There was also no association after accounting for hormone therapy use after RRSO. These findings suggest that RRSO should not be considered efficacious for reducing breast cancer risk.
Identifiants
pubmed: 30496449
pii: 5212812
doi: 10.1093/jnci/djy182
pmc: PMC6410936
doi:
Substances chimiques
BRCA1 Protein
0
BRCA1 protein, human
0
BRCA2 Protein
0
BRCA2 protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
331-334Subventions
Organisme : NCI NIH HHS
ID : T32 CA094061
Pays : United States
Organisme : NCATS NIH HHS
ID : TL1 TR001875
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA164920
Pays : United States
Informations de copyright
© The Author(s) 2018. Published by Oxford University Press.
Références
Hum Mutat. 2002 Jul;20(1):65-73
pubmed: 12112659
Breast Cancer Res. 2004;6(4):R375-89
pubmed: 15217505
Br J Cancer. 2004 Oct 18;91(8):1580-90
pubmed: 15381934
J Clin Oncol. 2005 Oct 20;23(30):7491-6
pubmed: 16234515
J Natl Compr Canc Netw. 2006 Feb;4(2):177-82
pubmed: 16451773
J Clin Oncol. 2008 Mar 10;26(8):1331-7
pubmed: 18268356
Breast Cancer Res Treat. 2009 Jul;116(2):379-86
pubmed: 18704680
JAMA. 2010 Sep 1;304(9):967-75
pubmed: 20810374
J Natl Cancer Inst. 2015 Mar 18;107(5):null
pubmed: 25788320
Int J Epidemiol. 2016 Jun;45(3):683-92
pubmed: 26174520
J Natl Cancer Inst. 2016 Sep 06;109(1):
pubmed: 27601060
JAMA. 2017 Jun 20;317(23):2402-2416
pubmed: 28632866