Blue light exposure in vitro causes toxicity to trigeminal neurons and glia through increased superoxide and hydrogen peroxide generation.
Animals
Cell Death
/ radiation effects
Dose-Response Relationship, Radiation
Endoplasmic Reticulum
/ metabolism
Gene Expression
/ radiation effects
Hydrogen Peroxide
/ agonists
Light
/ adverse effects
Light Signal Transduction
Membrane Proteins
/ genetics
Mice
Mitochondria
/ metabolism
Neuroglia
/ metabolism
Neurons
/ metabolism
Opsins
/ genetics
Oxidative Stress
/ radiation effects
Primary Cell Culture
Rod Opsins
/ genetics
Superoxides
/ agonists
Trigeminal Ganglion
/ metabolism
Blue light
Glial cells
Neurophototoxicity
Non-visual opsins
Trigeminal neural cells
Journal
Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159
Informations de publication
Date de publication:
01 02 2019
01 02 2019
Historique:
received:
17
10
2018
revised:
22
11
2018
accepted:
22
11
2018
pubmed:
30
11
2018
medline:
22
1
2020
entrez:
30
11
2018
Statut:
ppublish
Résumé
Today the noxiousness of blue light from natural and particularly artificial (fluorescent tubes, LED panels, visual displays) sources is actively discussed in the context of various ocular diseases. Many of them have an important neurologic component and are associated with ocular pain. This neuropathic signal is provided by nociceptive neurons from trigeminal ganglia. However, the phototoxicity of blue light on trigeminal neurons has not been explored so far. The aim of the present in vitro study was to investigate the cytotoxic impact of various wavebands of visible light (410-630 nm) on primary cell culture of mouse trigeminal neural and glial cells. Three-hour exposure to narrow wavebands of blue light centered at 410, 440 and 480 nm of average 1.1 mW/cm
Identifiants
pubmed: 30496813
pii: S0891-5849(18)32232-9
doi: 10.1016/j.freeradbiomed.2018.11.029
pii:
doi:
Substances chimiques
Membrane Proteins
0
OPN5 protein, mouse
0
Opsins
0
Rod Opsins
0
melanopsin
0
Superoxides
11062-77-4
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
27-39Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.