Non-genomic Effects of Glucocorticoids: An Updated View.
airway remodeling
asthma
corticosteroids
glucocorticoid receptor
non-genomic
smooth muscle
Journal
Trends in pharmacological sciences
ISSN: 1873-3735
Titre abrégé: Trends Pharmacol Sci
Pays: England
ID NLM: 7906158
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
20
08
2018
revised:
09
10
2018
accepted:
01
11
2018
pubmed:
1
12
2018
medline:
8
2
2019
entrez:
1
12
2018
Statut:
ppublish
Résumé
Glucocorticoid (GC) anti-inflammatory effects generally require a prolonged onset of action and involve genomic processes. Because of the rapidity of some of the GC effects, however, the concept that non-genomic actions may contribute to GC mechanisms of action has arisen. While the mechanisms have not been completely elucidated, the non-genomic effects may play a role in the management of inflammatory diseases. For instance, we recently reported that GCs 'rapidly' enhanced the effects of bronchodilators, agents used in the treatment of allergic asthma. In this review article, we discuss (i) the non-genomic effects of GCs on pathways relevant to the pathogenesis of inflammatory diseases and (ii) the putative role of the membrane GC receptor. Since GC side effects are often considered to be generated through its genomic actions, understanding GC non-genomic effects will help design GCs with a better therapeutic index.
Identifiants
pubmed: 30497693
pii: S0165-6147(18)30208-6
doi: 10.1016/j.tips.2018.11.002
pmc: PMC7106476
mid: NIHMS1515222
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Glucocorticoids
0
Receptors, Glucocorticoid
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
38-49Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL114471
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM107094
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL111541
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
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