A nationwide survey on non-B, non-C hepatocellular carcinoma in Japan: 2011-2015 update.
Alcoholic liver disease
Hepatocellular carcinoma
Non-alcoholic fatty liver disease
Journal
Journal of gastroenterology
ISSN: 1435-5922
Titre abrégé: J Gastroenterol
Pays: Japan
ID NLM: 9430794
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
01
10
2018
accepted:
21
11
2018
pubmed:
1
12
2018
medline:
19
5
2020
entrez:
1
12
2018
Statut:
ppublish
Résumé
We previously reported that the incidence of hepatocellular carcinoma (HCC) with non-viral etiologies increased rapidly between 1991 and 2010 in Japan. To update this investigation, we enrolled patients who were initially diagnosed as having non-B, non-C HCC at participating hospitals between 2011 and 2015. In addition to the patient characteristics investigated in the previous report, we also investigated the duration of alcohol consumption. The overall survival rate was analyzed using the Kaplan-Meier method, and the hazard function against the body mass index (BMI) was plotted using cubic splines. A total of 2087 patients were enrolled. The proportion of patients with non-viral etiologies has continued to increase from 10.0% in 1991 to 32.5% in 2015. Patients were also older (median ages, 70-73 years) and more obese (median BMIs, 23.9-24.2 kg/m The proportion of HCC patients with non-viral etiologies continues to increase in Japan. Lifetime total amount of alcohol consumption may be a risk factor.
Sections du résumé
BACKGROUND
BACKGROUND
We previously reported that the incidence of hepatocellular carcinoma (HCC) with non-viral etiologies increased rapidly between 1991 and 2010 in Japan.
METHODS
METHODS
To update this investigation, we enrolled patients who were initially diagnosed as having non-B, non-C HCC at participating hospitals between 2011 and 2015. In addition to the patient characteristics investigated in the previous report, we also investigated the duration of alcohol consumption. The overall survival rate was analyzed using the Kaplan-Meier method, and the hazard function against the body mass index (BMI) was plotted using cubic splines.
RESULTS
RESULTS
A total of 2087 patients were enrolled. The proportion of patients with non-viral etiologies has continued to increase from 10.0% in 1991 to 32.5% in 2015. Patients were also older (median ages, 70-73 years) and more obese (median BMIs, 23.9-24.2 kg/m
CONCLUSIONS
CONCLUSIONS
The proportion of HCC patients with non-viral etiologies continues to increase in Japan. Lifetime total amount of alcohol consumption may be a risk factor.
Identifiants
pubmed: 30498904
doi: 10.1007/s00535-018-1532-5
pii: 10.1007/s00535-018-1532-5
pmc: PMC6437291
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
367-376Subventions
Organisme : Japan Agency for Medical Research and Development
ID : JP17fk0210304
Organisme : Japan Agency for Medical Research and Development
ID : JP18fk0210040
Organisme : Ministry of Health, Labour and Welfare
ID : H30-Kansei-Shitei-003
Commentaires et corrections
Type : CommentIn
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