Vasoactive Intestinal Peptide Decreases β-Amyloid Accumulation and Prevents Brain Atrophy in the 5xFAD Mouse Model of Alzheimer's Disease.
5xFAD
Alzheimer’s disease
Brain atrophy
Neuroinflammation
Vasoactive intestinal peptide
β-Amyloid plaques
Journal
Journal of molecular neuroscience : MN
ISSN: 1559-1166
Titre abrégé: J Mol Neurosci
Pays: United States
ID NLM: 9002991
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
06
04
2018
accepted:
21
11
2018
pubmed:
1
12
2018
medline:
18
12
2019
entrez:
1
12
2018
Statut:
ppublish
Résumé
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by extracellular deposits of fibrillary β-amyloid (Aβ) plaques in the brain that initiate an inflammatory process resulting in neurodegeneration. The neuronal loss associated with AD results in gross atrophy of affected regions causing a progressive loss of cognitive ability and memory function, ultimately leading to dementia. Growing evidence suggests that vasoactive intestinal peptide (VIP) could be beneficial for various neurodegenerative diseases, including AD. The study investigated the effects of VIP on 5xFAD, a transgenic mouse model of AD. Toward this aim, we used 20 5xFAD mice in two groups (n = 10 each), VIP-treated (25 ng/kg i.p. injection, three times per week) and saline-treated (the drug's vehicle) following the same administration regimen. Treatment started at 1 month of age and ended 2 months later. After 2 months of treatment, the mice were euthanized, their brains dissected out, and immunohistochemically stained for Aβ
Identifiants
pubmed: 30498985
doi: 10.1007/s12031-018-1226-8
pii: 10.1007/s12031-018-1226-8
doi:
Substances chimiques
Amyloid beta-Peptides
0
Neuroprotective Agents
0
Vasoactive Intestinal Peptide
37221-79-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
389-396Subventions
Organisme : NIA NIH HHS
ID : R01AG031896
Pays : United States
Organisme : National Institute on Aging
ID : P30AG013846
Organisme : Türkiye Bilimsel ve Teknolojik Araştirma Kurumu
ID : 1059B190900502
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