Noninvasive Quantification of Axonal Loss in the Presence of Tissue Swelling in Traumatic Spinal Cord Injury Mice.
axonal injury
axonal volume
demyelination
diffusion MRI
inflammation
lesion cavity
spinal cord injury
Journal
Journal of neurotrauma
ISSN: 1557-9042
Titre abrégé: J Neurotrauma
Pays: United States
ID NLM: 8811626
Informations de publication
Date de publication:
01 08 2019
01 08 2019
Historique:
pubmed:
7
12
2018
medline:
5
11
2020
entrez:
4
12
2018
Statut:
ppublish
Résumé
Neuroimaging plays an important role in assessing axonal pathology after traumatic spinal cord injury. However, coexisting inflammation confounds imaging assessment of the severity of axonal injury. Herein, we applied diffusion basis spectrum imaging (DBSI) to quantitatively differentiate and quantify underlying pathologies in traumatic spinal cord injury at 3 days post-injury. Results reveal that DBSI was capable of detecting and differentiating axonal injury, demyelination, and inflammation-associated edema and cell infiltration in contusion-injured spinal cords. DBSI was able to detect and quantify axonal loss in the presence of white matter tract swelling. The DBSI-defined apparent axonal volume correlated with the corresponding histological markers. DBSI-derived pathological metrics could serve as neuroimaging biomarkers to differentiate and quantify coexisting white matter pathologies in spinal cord injury, providing potential surrogate outcome measures to assess spinal cord injury progression and response to therapies.
Identifiants
pubmed: 30501460
doi: 10.1089/neu.2018.6016
pmc: PMC6648203
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
2308-2315Subventions
Organisme : NINDS NIH HHS
ID : P01 NS059560
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS047592
Pays : United States
Organisme : NEI NIH HHS
ID : U01 EY025500
Pays : United States
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