New approaches for the treatment of Alzheimer's disease.

Alzheimer Disease / drug therapy Amyloid beta-Peptides / antagonists & inhibitors Animals Humans Neuroprotective Agents / chemistry
Alzheimer’s disease Disease modification Drug discovery pipeline Neurodegeneration Neuroinflammation Symptomatic treatments

Journal

Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377

Informations de publication

Date de publication:
15 01 2019
Historique:
received: 09 10 2018
revised: 15 11 2018
accepted: 15 11 2018
pubmed: 5 12 2018
medline: 5 11 2019
entrez: 4 12 2018
Statut: ppublish

Résumé

Alzheimer's disease (AD) is the most prevalent chronic neurodegenerative disease. Current approved therapies are symptomatic treatments having some effect on cognitive function. Therapies that target β-amyloid (Aβ) have been the focus of efforts to develop a disease modification treatment for AD but these approaches have failed to show any clinical benefit so far. Beyond the 'Aβ hypothesis', there are a number of newer approaches to treat AD with neuroinflammation emerging as a very active area of research based on risk gene analysis. This short review will summarize approved drug therapies, recent clinical trials and new approaches for the treatment of AD.

Identifiants

DOI: 10.1016/j.bmcl.2018.11.034 PMID: 30501965
pubmed: 30501965
pii: S0960-894X(18)30901-6
doi: 10.1016/j.bmcl.2018.11.034
pii:
doi:

Substances chimiques

Amyloid beta-Peptides 0
Neuroprotective Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

125-133

Subventions

Organisme : Cancer Research UK
ID : FC001002
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001002
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M02492X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : FC001002
Pays : United Kingdom

Informations de copyright

Copyright © 2018 Elsevier Ltd. All rights reserved.

Auteurs

Paul V Fish (PV)

Alzheimer's Research UK UCL Drug Discovery Institute, The Cruciform Building, University College London, Gower Street, London WC1N 1E 6BT, UK; The Francis Crick Institute, 1 Midland Road, Kings Cross, London NW1 1AT, UK. Electronic address: p.fish@ucl.ac.uk.

David Steadman (D)

Alzheimer's Research UK UCL Drug Discovery Institute, The Cruciform Building, University College London, Gower Street, London WC1N 1E 6BT, UK.

Elliott D Bayle (ED)

Alzheimer's Research UK UCL Drug Discovery Institute, The Cruciform Building, University College London, Gower Street, London WC1N 1E 6BT, UK; The Francis Crick Institute, 1 Midland Road, Kings Cross, London NW1 1AT, UK.

Paul Whiting (P)

Alzheimer's Research UK UCL Drug Discovery Institute, The Cruciform Building, University College London, Gower Street, London WC1N 1E 6BT, UK; The Dementia Research Institute, The Cruciform Building, University College London, Gower Street, London WC1N 1E 6BT, UK.

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › New approaches for the treatment of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Peptides bêta-amyloïdes › New approaches for the treatment of...
questionsmedicales.fr › Eucaryotes › Animaux › New approaches for the treatment of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › New approaches for the treatment of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Neuroprotecteurs › New approaches for the treatment of...