David Steadman

Affiliations

Department of Chemistry, University College London, UK.

Publications (8)

Engineering transketolase to accept both unnatural donor and acceptor substrates and produce α-hydroxyketones.

The FEBS journal

Avec: Haoran Yu , Roberto Icken Hernández López , David Steadman , Daniel Méndez-Sánchez , Sally Higson , Armando Cázares-Körner , Tom D Sheppard , John M Ward , Helen C Hailes , Paul A Dalby

Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.

Journal of medicinal chemistry

Avec: William Mahy , Mikesh Patel , David Steadman , Hannah L Woodward , Benjamin N Atkinson , Fredrik Svensson , Nicky J Willis , Alister Flint , Dimitra Papatheodorou , Yuguang Zhao , Luca Vecchia , Reinis R Ruza , James Hillier , Sarah Frew , Amy Monaghan , Artur Costa , Magda Bictash , Magnus W Walter , E Yvonne Jones , Paul V Fish

The emergency surgery score (ESS) and outcomes in elderly patients undergoing emergency laparotomy: A post-hoc analysis of an EAST multicenter study.

American journal of surgery

Avec: Majed El Hechi , Napaporn Kongkaewpaisan , Mohamad El Moheb , Brittany Aicher , Jose Diaz , Lindsay OʼMeara , Cassandra Decker , Jennifer Rodriquez , Thomas Schroeppel , Rishi Rattan , Georgia Vasileiou , D Dante Yeh , Ursula Simonosk , David Turay , Daniel Cullinane , Cory Emmert , Marta McCrum , Natalie Wall , Jeremy Badach , Anna Goldenberg-Sanda , Heather Carmichael , Catherine Velopulos , Rachel Choron , Joseph Sakran , Khaldoun Bekdache , George Black , Thomas Shoultz , Zachary Chadnick , Vasiliy Sim , Firas Madbak , Daniel Steadman , Maraya Camazine , Martin Zielinski , Claire Hardman , Mbaga Walusimbi , Mirhee Kim , Simon Rodier , Vasileios Papadopoulos , Georgios Tsoulfas , Javier Perez , Haytham Kaafarani

A conserved interdomain microbial network underpins cadaver decomposition despite environmental variables.

Nature microbiology

Avec: Zachary M Burcham , Aeriel D Belk , Bridget B McGivern , Amina Bouslimani , Parsa Ghadermazi , Cameron Martino , Liat Shenhav , Anru R Zhang , Pixu Shi , Alexandra Emmons , Heather L Deel , Zhenjiang Zech Xu , Victoria Nieciecki , Qiyun Zhu , Michael Shaffer , Morgan Panitchpakdi , Kelly C Weldon , Kalen Cantrell , Asa Ben-Hur , Sasha C Reed , Greg C Humphry , Gail Ackermann , Daniel McDonald , Siu Hung Joshua Chan , Melissa Connor , Derek Boyd , Jake Smith , Jenna M S Watson , Giovanna Vidoli , Dawnie Steadman , Aaron M Lynne , Sibyl Bucheli , Pieter C Dorrestein , Kelly C Wrighton , David O Carter , Rob Knight , Jessica L Metcalf

Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.

MedChemComm

Avec: Benjamin N Atkinson , David Steadman , Yuguang Zhao , James Sipthorp , Luca Vecchia , Reinis R Ruza , Fiona Jeganathan , Georgie Lines , Sarah Frew , Amy Monaghan , Svend Kjær , Magda Bictash , E Yvonne Jones , Paul V Fish

Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.

Journal of medicinal chemistry

Avec: David Steadman , Benjamin N Atkinson , Yuguang Zhao , Nicky J Willis , Sarah Frew , Amy Monaghan , Chandni Patel , Emma Armstrong , Kathryn Costelloe , Lorenza Magno , Magda Bictash , E Yvonne Jones , Paul V Fish , Fredrik Svensson

New approaches for the treatment of Alzheimer's disease.

Bioorganic & medicinal chemistry letters

Avec: Paul V Fish , David Steadman , Elliott D Bayle , Paul Whiting

Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors.

Bioorganic & medicinal chemistry letters

Avec: Benjamin N Atkinson , David Steadman , William Mahy , Yuguang Zhao , James Sipthorp , Elliott D Bayle , Fredrik Svensson , George Papageorgiou , Fiona Jeganathan , Sarah Frew , Amy Monaghan , Magda Bictash , E Yvonne Jones , Paul V Fish

Réseau de co-auteurs

Paul V Fish 5 collaborations

Benjamin N Atkinson 4 collaborations

Yuguang Zhao 4 collaborations

Sarah Frew 4 collaborations

Amy Monaghan 4 collaborations

Magda Bictash 4 collaborations

E Yvonne Jones 4 collaborations

Fredrik Svensson 3 collaborations

William Mahy 2 collaborations

Nicky J Willis 2 collaborations

Luca Vecchia 2 collaborations

Reinis R Ruza 2 collaborations

James Sipthorp 2 collaborations

Fiona Jeganathan 2 collaborations

Elliott D Bayle 2 collaborations

Haoran Yu 1 collaboration

Roberto Icken Hernández López 1 collaboration

Daniel Méndez-Sánchez 1 collaboration

Sally Higson 1 collaboration

Armando Cázares-Körner 1 collaboration

Tom D Sheppard 1 collaboration

John M Ward 1 collaboration

Helen C Hailes 1 collaboration

Paul A Dalby 1 collaboration

Mikesh Patel 1 collaboration

Hannah L Woodward 1 collaboration

Alister Flint 1 collaboration

Dimitra Papatheodorou 1 collaboration

James Hillier 1 collaboration

Artur Costa 1 collaboration

Magnus W Walter 1 collaboration

Majed El Hechi 1 collaboration

Napaporn Kongkaewpaisan 1 collaboration

Mohamad El Moheb 1 collaboration

Brittany Aicher 1 collaboration

Jose Diaz 1 collaboration

Lindsay OʼMeara 1 collaboration

Cassandra Decker 1 collaboration

Jennifer Rodriquez 1 collaboration

Thomas Schroeppel 1 collaboration

Rishi Rattan 1 collaboration

Georgia Vasileiou 1 collaboration

D Dante Yeh 1 collaboration

Ursula Simonosk 1 collaboration

David Turay 1 collaboration

Daniel Cullinane 1 collaboration

Cory Emmert 1 collaboration

Marta McCrum 1 collaboration

Natalie Wall 1 collaboration

Jeremy Badach 1 collaboration

Anna Goldenberg-Sanda 1 collaboration

Heather Carmichael 1 collaboration

Catherine Velopulos 1 collaboration

Rachel Choron 1 collaboration

Joseph Sakran 1 collaboration

Khaldoun Bekdache 1 collaboration

George Black 1 collaboration

Thomas Shoultz 1 collaboration

Zachary Chadnick 1 collaboration

Vasiliy Sim 1 collaboration

Firas Madbak 1 collaboration

Daniel Steadman 1 collaboration

Maraya Camazine 1 collaboration

Martin Zielinski 1 collaboration

Claire Hardman 1 collaboration

Mbaga Walusimbi 1 collaboration

Mirhee Kim 1 collaboration

Simon Rodier 1 collaboration

Vasileios Papadopoulos 1 collaboration

Georgios Tsoulfas 1 collaboration

Javier Perez 1 collaboration

Haytham Kaafarani 1 collaboration

Zachary M Burcham 1 collaboration

Aeriel D Belk 1 collaboration

Bridget B McGivern 1 collaboration

Amina Bouslimani 1 collaboration

Parsa Ghadermazi 1 collaboration

Cameron Martino 1 collaboration

Liat Shenhav 1 collaboration

Anru R Zhang 1 collaboration

Pixu Shi 1 collaboration

Alexandra Emmons 1 collaboration

Heather L Deel 1 collaboration

Zhenjiang Zech Xu 1 collaboration

Victoria Nieciecki 1 collaboration

Qiyun Zhu 1 collaboration

Michael Shaffer 1 collaboration

Morgan Panitchpakdi 1 collaboration

Kelly C Weldon 1 collaboration

Kalen Cantrell 1 collaboration

Asa Ben-Hur 1 collaboration

Sasha C Reed 1 collaboration

Greg C Humphry 1 collaboration

Gail Ackermann 1 collaboration

Daniel McDonald 1 collaboration

Siu Hung Joshua Chan 1 collaboration

Melissa Connor 1 collaboration

Derek Boyd 1 collaboration

Jake Smith 1 collaboration

Jenna M S Watson 1 collaboration

Giovanna Vidoli 1 collaboration

Dawnie Steadman 1 collaboration

Aaron M Lynne 1 collaboration

Sibyl Bucheli 1 collaboration

Pieter C Dorrestein 1 collaboration

Kelly C Wrighton 1 collaboration

David O Carter 1 collaboration

Rob Knight 1 collaboration

Jessica L Metcalf 1 collaboration

Georgie Lines 1 collaboration

Svend Kjær 1 collaboration

Chandni Patel 1 collaboration

Emma Armstrong 1 collaboration

Kathryn Costelloe 1 collaboration

Lorenza Magno 1 collaboration

Paul Whiting 1 collaboration

George Papageorgiou 1 collaboration