Luca Vecchia

Affiliations

Division of Structural Biology, Wellcome Centre for Human Genetics, University of Oxford, The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, U.K.

Publications (13)

Structural Analysis and Development of Notum Fragment Screening Hits.

ACS chemical neuroscience

Avec: Yuguang Zhao , William Mahy , Nicky J Willis , Hannah L Woodward , David Steadman , Elliott D Bayle , Benjamin N Atkinson , James Sipthorp , Luca Vecchia , Reinis R Ruza , Karl Harlos , Fiona Jeganathan , Stefan Constantinou , Artur Costa , Svend Kjær , Magda Bictash , Patricia C Salinas , Paul Whiting , Jean-Paul Vincent , Paul V Fish , E Yvonne Jones

Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.

MedChemComm

Avec: Benjamin N Atkinson , David Steadman , Yuguang Zhao , James Sipthorp , Luca Vecchia , Reinis R Ruza , Fiona Jeganathan , Georgie Lines , Sarah Frew , Amy Monaghan , Svend Kjær , Magda Bictash , E Yvonne Jones , Paul V Fish

Cooperation between bHLH transcription factors and histones for DNA access.

Nature

Avec: Alicia K Michael , Lisa Stoos , Priya Crosby , Nikolas Eggers , Xinyu Y Nie , Kristina Makasheva , Martina Minnich , Kelly L Healy , Joscha Weiss , Georg Kempf , Simone Cavadini , Lukas Kater , Jan Seebacher , Luca Vecchia , Deyasini Chakraborty , Luke Isbel , Ralph S Grand , Florian Andersch , Jennifer L Fribourgh , Dirk Schübeler , Johannes Zuber , Andrew C Liu , Peter B Becker , Beat Fierz , Carrie L Partch , Jerome S Menet , Nicolas H Thomä

Glypicans shield the Wnt lipid moiety to enable signalling at a distance.

Nature

Avec: Ian J McGough , Luca Vecchia , Benjamin Bishop , Tomas Malinauskas , Karen Beckett , Dhira Joshi , Nicola O'Reilly , Christian Siebold , E Yvonne Jones , Jean-Paul Vincent

Performance evaluation of the high sensitive troponin I assay on the Atellica IM analyser.

Biochemia medica

Avec: Antonio Buño Soto , Katell Peoc'h , Tommaso Fasano , Jorge Diaz-Garzon , Bernardino González de la Presa , Valerie Chicha-Cattoir , Simone Canovi , Maria Sanz de Pedro , Nayra Rico , Tiphaine Robert , Efrem Bonelli , Pilar Fernández Calle , Aurea Mira , Guillaume Lefevre , Luigi Vecchia , Jose Luis Bedini

Multi-site performance evaluation and Sigma metrics of 20 assays on the Atellica chemistry and immunoassay analyzers.

Clinical chemistry and laboratory medicine

Avec: Tommaso Fasano , Jose Luis Bedini , Pierre-Antoine Fle , Malik Jlaiel , Karl Hubbert , Harish Datta , Valerie Chicha-Cattoir , Hayfa Mansour , Aurea Mira , Bernardino González de la Presa , Nayra Rico , Maria Sanz de Pedro , Jorge Diaz-Garzon , Antonio Buño Soto , Luigi Vecchia , Katell Peoc'h

Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity.

Journal of medicinal chemistry

Avec: William Mahy , Mikesh Patel , David Steadman , Hannah L Woodward , Benjamin N Atkinson , Fredrik Svensson , Nicky J Willis , Alister Flint , Dimitra Papatheodorou , Yuguang Zhao , Luca Vecchia , Reinis R Ruza , James Hillier , Sarah Frew , Amy Monaghan , Artur Costa , Magda Bictash , Magnus W Walter , E Yvonne Jones , Paul V Fish

Experimental phasing opportunities for macromolecular crystallography at very long wavelengths.

Communications chemistry

Avec: Kamel El Omari , Ramona Duman , Vitaliy Mykhaylyk , Christian M Orr , Merlyn Latimer-Smith , Graeme Winter , Vinay Grama , Feng Qu , Kiran Bountra , Hok Sau Kwong , Maria Romano , Rosana I Reis , Lutz Vogeley , Luca Vecchia , C David Owen , Sina Wittmann , Max Renner , Miki Senda , Naohiro Matsugaki , Yoshiaki Kawano , Thomas A Bowden , Isabel Moraes , Jonathan M Grimes , Erika J Mancini , Martin A Walsh , Cristiane R Guzzo , Raymond J Owens , E Yvonne Jones , David G Brown , Dave I Stuart , Konstantinos Beis , Armin Wagner

Pregnancy-related reference intervals for serum thyrotropin based on real-life clinical data.

Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology

Avec: Simone Canovi , Silvia Vezzani , Alessandra Polese , Andrea Frasoldati , Clara Schiatti , Cristina Preda , Michele Corradini Zini , Antonio Vitiello , Marco Foracchia , Giuseppina Comitini , Lorenzo Aguzzoli , Tommaso Fasano , Luigi Vecchia

5-Phenyl-1,3,4-oxadiazol-2(3

Journal of medicinal chemistry

Avec: William Mahy , Nicky J Willis , Yuguang Zhao , Hannah L Woodward , Fredrik Svensson , James Sipthorp , Luca Vecchia , Reinis R Ruza , James Hillier , Svend Kjær , Sarah Frew , Amy Monaghan , Magda Bictash , Patricia C Salinas , Paul Whiting , Jean-Paul Vincent , E Yvonne Jones , Paul V Fish

New information flows for cancer registries: testing the use of laboratory data in the province of Reggio Emilia, Italy.

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)

Avec: Francesca Roncaglia , Pamela Mancuso , Massimo Vicentini , Antonio Vitiello , Luigi Vecchia , Stefano Luminari , Lucia Mangone , Manuel Zorzi , Carlo La Vecchia , Paolo Giorgi Rossi

Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.

Journal of medicinal chemistry

Avec: Nicky J Willis , William Mahy , James Sipthorp , Yuguang Zhao , Hannah L Woodward , Benjamin N Atkinson , Elliott D Bayle , Fredrik Svensson , Sarah Frew , Fiona Jeganathan , Amy Monaghan , Stefano Benvegnù , Sarah Jolly , Luca Vecchia , Reinis R Ruza , Svend Kjær , Steven Howell , Ambrosius P Snijders , Magda Bictash , Patricia C Salinas , Jean-Paul Vincent , E Yvonne Jones , Paul Whiting , Paul V Fish

Pioneer factors: Emerging rules of engagement for transcription factors on chromatinized DNA.

Current opinion in structural biology

Avec: Manuel Carminati , Luca Vecchia , Lisa Stoos , Nicolas H Thomä

Réseau de co-auteurs

E Yvonne Jones 7 collaborations

Yuguang Zhao 5 collaborations

Reinis R Ruza 5 collaborations

Magda Bictash 5 collaborations

Paul V Fish 5 collaborations

William Mahy 4 collaborations

Nicky J Willis 4 collaborations

Hannah L Woodward 4 collaborations

Benjamin N Atkinson 4 collaborations

James Sipthorp 4 collaborations

Svend Kjær 4 collaborations

Jean-Paul Vincent 4 collaborations

Sarah Frew 4 collaborations

Amy Monaghan 4 collaborations

Luigi Vecchia 4 collaborations

David Steadman 3 collaborations

Fiona Jeganathan 3 collaborations

Patricia C Salinas 3 collaborations

Paul Whiting 3 collaborations

Tommaso Fasano 3 collaborations

Fredrik Svensson 3 collaborations

Elliott D Bayle 2 collaborations

Artur Costa 2 collaborations

Lisa Stoos 2 collaborations

Nicolas H Thomä 2 collaborations

Antonio Buño Soto 2 collaborations

Katell Peoc'h 2 collaborations

Jorge Diaz-Garzon 2 collaborations

Bernardino González de la Presa 2 collaborations

Valerie Chicha-Cattoir 2 collaborations

Simone Canovi 2 collaborations

Maria Sanz de Pedro 2 collaborations

Nayra Rico 2 collaborations

Aurea Mira 2 collaborations

Jose Luis Bedini 2 collaborations

James Hillier 2 collaborations

Antonio Vitiello 2 collaborations

Karl Harlos 1 collaboration

Stefan Constantinou 1 collaboration

Georgie Lines 1 collaboration

Alicia K Michael 1 collaboration

Priya Crosby 1 collaboration

Nikolas Eggers 1 collaboration

Xinyu Y Nie 1 collaboration

Kristina Makasheva 1 collaboration

Martina Minnich 1 collaboration

Kelly L Healy 1 collaboration

Joscha Weiss 1 collaboration

Georg Kempf 1 collaboration

Simone Cavadini 1 collaboration

Lukas Kater 1 collaboration

Jan Seebacher 1 collaboration

Deyasini Chakraborty 1 collaboration

Luke Isbel 1 collaboration

Ralph S Grand 1 collaboration

Florian Andersch 1 collaboration

Jennifer L Fribourgh 1 collaboration

Dirk Schübeler 1 collaboration

Johannes Zuber 1 collaboration

Andrew C Liu 1 collaboration

Peter B Becker 1 collaboration

Beat Fierz 1 collaboration

Carrie L Partch 1 collaboration

Jerome S Menet 1 collaboration

Ian J McGough 1 collaboration

Benjamin Bishop 1 collaboration

Tomas Malinauskas 1 collaboration

Karen Beckett 1 collaboration

Dhira Joshi 1 collaboration

Nicola O'Reilly 1 collaboration

Christian Siebold 1 collaboration

Tiphaine Robert 1 collaboration

Efrem Bonelli 1 collaboration

Pilar Fernández Calle 1 collaboration

Guillaume Lefevre 1 collaboration

Pierre-Antoine Fle 1 collaboration

Malik Jlaiel 1 collaboration

Karl Hubbert 1 collaboration

Harish Datta 1 collaboration

Hayfa Mansour 1 collaboration

Mikesh Patel 1 collaboration

Alister Flint 1 collaboration

Dimitra Papatheodorou 1 collaboration

Magnus W Walter 1 collaboration

Kamel El Omari 1 collaboration

Ramona Duman 1 collaboration

Vitaliy Mykhaylyk 1 collaboration

Christian M Orr 1 collaboration

Merlyn Latimer-Smith 1 collaboration

Graeme Winter 1 collaboration

Vinay Grama 1 collaboration

Feng Qu 1 collaboration

Kiran Bountra 1 collaboration

Hok Sau Kwong 1 collaboration

Maria Romano 1 collaboration

Rosana I Reis 1 collaboration

Lutz Vogeley 1 collaboration

C David Owen 1 collaboration

Sina Wittmann 1 collaboration

Max Renner 1 collaboration

Miki Senda 1 collaboration

Naohiro Matsugaki 1 collaboration

Yoshiaki Kawano 1 collaboration

Thomas A Bowden 1 collaboration

Isabel Moraes 1 collaboration

Jonathan M Grimes 1 collaboration

Erika J Mancini 1 collaboration

Martin A Walsh 1 collaboration

Cristiane R Guzzo 1 collaboration

Raymond J Owens 1 collaboration

David G Brown 1 collaboration

Dave I Stuart 1 collaboration

Konstantinos Beis 1 collaboration

Armin Wagner 1 collaboration

Silvia Vezzani 1 collaboration

Alessandra Polese 1 collaboration

Andrea Frasoldati 1 collaboration

Clara Schiatti 1 collaboration

Cristina Preda 1 collaboration

Michele Corradini Zini 1 collaboration

Marco Foracchia 1 collaboration

Giuseppina Comitini 1 collaboration

Lorenzo Aguzzoli 1 collaboration

Francesca Roncaglia 1 collaboration

Pamela Mancuso 1 collaboration

Massimo Vicentini 1 collaboration

Stefano Luminari 1 collaboration

Lucia Mangone 1 collaboration

Manuel Zorzi 1 collaboration

Carlo La Vecchia 1 collaboration

Paolo Giorgi Rossi 1 collaboration

Stefano Benvegnù 1 collaboration

Sarah Jolly 1 collaboration

Steven Howell 1 collaboration

Ambrosius P Snijders 1 collaboration

Manuel Carminati 1 collaboration