Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen.


Journal

MedChemComm
ISSN: 2040-2511
Titre abrégé: Medchemcomm
Pays: England
ID NLM: 101531525

Informations de publication

Date de publication:
01 Aug 2019
Historique:
received: 15 02 2019
accepted: 11 04 2019
entrez: 20 9 2019
pubmed: 20 9 2019
medline: 20 9 2019
Statut: epublish

Résumé

NOTUM is a carboxylesterase that has been shown to act by mediating the

Identifiants

pubmed: 31534655
doi: 10.1039/c9md00096h
pii: c9md00096h
pmc: PMC6727465
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1361-1369

Subventions

Organisme : Cancer Research UK
ID : FC001002
Pays : United Kingdom
Organisme : Medical Research Council
ID : FC001002
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001002
Pays : United Kingdom

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Auteurs

Benjamin N Atkinson (BN)

Alzheimer's Research UK UCL Drug Discovery Institute , University College London , Cruciform Building, Gower Street , London , WC1E 6BT , UK . Email: p.fish@ucl.ac.uk ; Tel: +44 (0)20 7679 6971.

David Steadman (D)

Alzheimer's Research UK UCL Drug Discovery Institute , University College London , Cruciform Building, Gower Street , London , WC1E 6BT , UK . Email: p.fish@ucl.ac.uk ; Tel: +44 (0)20 7679 6971.

Yuguang Zhao (Y)

Division of Structural Biology , Wellcome Centre for Human Genetics , University of Oxford , The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive , Oxford , OX3 7BN , UK . Email: yvonne@strubi.ox.ac.uk ; Tel: +44 (0)1865 287 546.

James Sipthorp (J)

Alzheimer's Research UK UCL Drug Discovery Institute , University College London , Cruciform Building, Gower Street , London , WC1E 6BT , UK . Email: p.fish@ucl.ac.uk ; Tel: +44 (0)20 7679 6971.
The Francis Crick Institute , 1 Midland Road , London , NW1 1AT , UK.

Luca Vecchia (L)

Division of Structural Biology , Wellcome Centre for Human Genetics , University of Oxford , The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive , Oxford , OX3 7BN , UK . Email: yvonne@strubi.ox.ac.uk ; Tel: +44 (0)1865 287 546.

Reinis R Ruza (RR)

Division of Structural Biology , Wellcome Centre for Human Genetics , University of Oxford , The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive , Oxford , OX3 7BN , UK . Email: yvonne@strubi.ox.ac.uk ; Tel: +44 (0)1865 287 546.

Fiona Jeganathan (F)

Alzheimer's Research UK UCL Drug Discovery Institute , University College London , Cruciform Building, Gower Street , London , WC1E 6BT , UK . Email: p.fish@ucl.ac.uk ; Tel: +44 (0)20 7679 6971.

Georgie Lines (G)

Alzheimer's Research UK UCL Drug Discovery Institute , University College London , Cruciform Building, Gower Street , London , WC1E 6BT , UK . Email: p.fish@ucl.ac.uk ; Tel: +44 (0)20 7679 6971.

Sarah Frew (S)

Alzheimer's Research UK UCL Drug Discovery Institute , University College London , Cruciform Building, Gower Street , London , WC1E 6BT , UK . Email: p.fish@ucl.ac.uk ; Tel: +44 (0)20 7679 6971.

Amy Monaghan (A)

Alzheimer's Research UK UCL Drug Discovery Institute , University College London , Cruciform Building, Gower Street , London , WC1E 6BT , UK . Email: p.fish@ucl.ac.uk ; Tel: +44 (0)20 7679 6971.

Svend Kjær (S)

The Francis Crick Institute , 1 Midland Road , London , NW1 1AT , UK.

Magda Bictash (M)

Alzheimer's Research UK UCL Drug Discovery Institute , University College London , Cruciform Building, Gower Street , London , WC1E 6BT , UK . Email: p.fish@ucl.ac.uk ; Tel: +44 (0)20 7679 6971.

E Yvonne Jones (EY)

Division of Structural Biology , Wellcome Centre for Human Genetics , University of Oxford , The Henry Wellcome Building for Genomic Medicine, Roosevelt Drive , Oxford , OX3 7BN , UK . Email: yvonne@strubi.ox.ac.uk ; Tel: +44 (0)1865 287 546.

Paul V Fish (PV)

Alzheimer's Research UK UCL Drug Discovery Institute , University College London , Cruciform Building, Gower Street , London , WC1E 6BT , UK . Email: p.fish@ucl.ac.uk ; Tel: +44 (0)20 7679 6971.
The Francis Crick Institute , 1 Midland Road , London , NW1 1AT , UK.

Classifications MeSH