Sulphur dioxide ameliorates colitis related pathophysiology and inflammation.
Apoptosis
Autophagy
ER stress
Inflammation
Oxidative stress
Sulphur dioxide
Journal
Toxicology
ISSN: 1879-3185
Titre abrégé: Toxicology
Pays: Ireland
ID NLM: 0361055
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
14
05
2018
revised:
13
11
2018
accepted:
28
11
2018
pubmed:
7
12
2018
medline:
24
5
2019
entrez:
4
12
2018
Statut:
ppublish
Résumé
Colitis is an inflammatory disease of the gastrointestinal tract. Inflammation, oxidative stress and cell death constitute the backbone of colitis. Most of the drugs prescribed for inflammatory bowel disease (IBD) have various side effects. In this scenario, we would like to determine the therapeutic role sulphur dioxide, a gaso-transmitter produced through the metabolism of cysteine in colitis. Colitis was induced through intrarectal administration of 2,4,6-trinitrobenzenesulfonic acid (TNBS) in male Wistar rats. Rats were administered with 0.9% saline containing Na
Identifiants
pubmed: 30503585
pii: S0300-483X(18)30631-0
doi: 10.1016/j.tox.2018.11.010
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Antioxidants
0
Cytokines
0
Sulfur Dioxide
0UZA3422Q4
Trinitrobenzenesulfonic Acid
8T3HQG2ZC4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
63-78Informations de copyright
Copyright © 2018 Elsevier B.V. All rights reserved.