Alternariol induced proliferation in primary mouse keratinocytes and inflammation in mouse skin is regulated via PGE
Animals
Cell Proliferation
/ drug effects
Cells, Cultured
Cyclic AMP
/ metabolism
Cyclic AMP Response Element-Binding Protein
/ metabolism
Cyclooxygenase 2
/ metabolism
Dinoprostone
/ metabolism
Female
Inflammation
/ chemically induced
Keratinocytes
/ drug effects
Lactones
/ toxicity
Mice
Receptors, Prostaglandin E, EP2 Subtype
/ metabolism
Signal Transduction
/ drug effects
Skin
/ drug effects
Alternariol
Mycotoxins
PGE(2)
Proliferation
Journal
Toxicology
ISSN: 1879-3185
Titre abrégé: Toxicology
Pays: Ireland
ID NLM: 0361055
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
23
06
2018
revised:
19
11
2018
accepted:
28
11
2018
pubmed:
7
12
2018
medline:
24
5
2019
entrez:
4
12
2018
Statut:
ppublish
Résumé
Alternariol (AOH) is a mycotoxin that contaminates various food stuffs as well as animal feed and may cause toxicity after consumption. However, a dermal toxic potential of AOH has not been explored so far. In the present study, skin toxicity after topical exposure of AOH and the involved mechanism/s are revealed. Single topical application of different AOH doses (12.5, 25, 50 μg/animal) caused increased bi-fold thickness as well as hyperplasia and higher production of prostaglandin E2 (PGE
Identifiants
pubmed: 30503586
pii: S0300-483X(18)30632-2
doi: 10.1016/j.tox.2018.11.013
pii:
doi:
Substances chimiques
Creb1 protein, mouse
0
Cyclic AMP Response Element-Binding Protein
0
Lactones
0
Receptors, Prostaglandin E, EP2 Subtype
0
Cyclic AMP
E0399OZS9N
Cyclooxygenase 2
EC 1.14.99.1
Dinoprostone
K7Q1JQR04M
alternariol
KN9L4260JW
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
79-88Informations de copyright
Copyright © 2018. Published by Elsevier B.V.